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UT GSBS Dissertations and Theses (Open Access)

Adenosine

2011

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

The Role Of Il-6 In Adenosine-Mediated Pulmonary Fibrosis, Mesias Pedroza May 2011

The Role Of Il-6 In Adenosine-Mediated Pulmonary Fibrosis, Mesias Pedroza

UT GSBS Dissertations and Theses (Open Access)

Adenosine is a purinergic signaling molecule that regulates various aspects of inflammation and has been implicated in the pathogenesis of chronic lung diseases. Previous studies have demonstrated that adenosine up-regulates IL-6 production through the engagement of the A2B adenosine receptor in various cell types, including alveolar macrophages. IL-6 is elevated in mouse models and humans with chronic lung disease, suggesting a potential role in disease progression. Furthermore, chronic elevation of adenosine in the lungs of adenosine deaminase deficient (Ada-/-) mice leads to the development of pulmonary inflammation, alveolar destruction, and fibrosis, in conjunction with IL-6 elevation. Thus, it was ...