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Biochemistry, Biophysics, and Structural Biology Commons

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Studies Of Hypoxia Response And Regulation Of Hypoxia-Inducible Factor Hif-1 In Caenorhabditis Elegans , Chuan Shen Jan 2006

Studies Of Hypoxia Response And Regulation Of Hypoxia-Inducible Factor Hif-1 In Caenorhabditis Elegans , Chuan Shen

Retrospective Theses and Dissertations

All aerobic organisms require molecular oxygen to generate metabolic energy for normal growth and survival. During evolution, multi-cellular organisms have developed and refined complex networks for adaptation to hypoxic environments at both systemic and cellular levels. Adaptation to hypoxia largely results from changes in the activity and expression of key proteins. These include proteins involved in increasing oxygen delivery to hypoxic tissues and proteins that facilitate glycolysis for anaerobic metabolism. The mammalian transcription factor hypoxia-inducible factor (HIF) is a master regulator of oxygen homeostasis. More than 100 target genes of HIF mediate broad systemic and local responses to hypoxia, including ...


Toxicity, Metabolism And Applied Uses Of 3,4-Didehydroretinol , Pamela Kay Duitsman Jan 1995

Toxicity, Metabolism And Applied Uses Of 3,4-Didehydroretinol , Pamela Kay Duitsman

Retrospective Theses and Dissertations

The comparative potencies of the all-trans isomers of 3,4-didehydroretinyl acetate (A2), retinyl acetate (A1), and retinoic acid (RA) to induce terata, embryolethality, and behavioral disruptions in offspring of timed-pregnant Sprague-Dawley rats was evaluated. Single equimolar doses (1-352 [mu]mol/kg BW) of the retinoids were given orally in corn oil on day 8.5 of gestation. All retinoids tested were teratogenic and embryolethal at dose ranges of 35-352 [mu]mol/kg BW. Embryolethality also occurred with both A2 and RA at 11 [mu]mol/kg BW. Biochemical profiles of both maternal and fetal tissue indicated that increased teratogenicity and ...


Effects Of Clofibric Acid On Porcine Hepatocytes: A New Model For The Study Of Peroxisomal Metabolism , Kenneth Wayne Turteltaub Jan 1987

Effects Of Clofibric Acid On Porcine Hepatocytes: A New Model For The Study Of Peroxisomal Metabolism , Kenneth Wayne Turteltaub

Retrospective Theses and Dissertations

Data on interspecies peroxisomal metabolism are limited almost entirely to rodents. Species differences are likely and the application of rodent data to man is questionable. An alternative to rodent models is desirable. Porcine tissue offers such an alternative and was explored. Porcine hepatocyte organelles were separated by isopycnic sucrose gradient centrifugation from livers of 6-month-old Yorkshire pigs. The presence of a peroxisomal palmityl-CoA oxidizing pathway, peroxisomal superoxide dismutase (SOD), and a peroxisomal NAD:aldehyde dehydrogenase (ALDH) with high K[subscript] m for acetaldehyde was demonstrated. Peroxisomal palmitate oxidizing capacity was found to be equal to that of the surviving mitochondria ...