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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Neuronal Functions Of Ahr-1, The Caenorhabditis Elegans Homolog Of The Aryl Hydrocarbon Receptor , Hongtao Qin
Retrospective Theses and Dissertations
The mammalian aryl hydrocarbon receptor (AHR) mediates the toxic effects of dioxins and related compounds. Toxicological and genetic studies have shown that AHR regulates important development events and physiological functions. Interestingly, AHR homologs are found in most metazoans, and studies of AHR regulation and function in invertebrate model systems may provide insight to the ancient functions of AHR. In this thesis, I analyze the endogenous functions of the ahr-1 gene in the nematode Caenorhabditis elegans. ahr-1:GFP is expressed in a subset of neurons. ahr-1 regulates the development of diverse neuronal cell types, including the AVM and PLM touch receptor ...