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Biochemistry, Biophysics, and Structural Biology Commons

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Retrospective Theses and Dissertations

2003

Microbiology

Articles 1 - 2 of 2

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Genetic And Phenotypic Variation Of The Equine Infectious Anemia Virus Surface Unit Envelope Glycoprotein During Disease Progression , Brett Alan Sponseller Jan 2003

Genetic And Phenotypic Variation Of The Equine Infectious Anemia Virus Surface Unit Envelope Glycoprotein During Disease Progression , Brett Alan Sponseller

Retrospective Theses and Dissertations

Lentiviruses are single-stranded RNA viruses generally associated with chronic diseases of the immune and central nervous systems. In contrast to the insidious, progressive nature of most lentiviral diseases, equine infectious anemia virus (EIAV) infection results in rapid onset of a variable disease course in equids. Acute disease is accompanied with high-titered viremia, thrombocytopenia, fever, depression, and inappetance. The chronic stage is usually characterized by recurrent episodes of disease. Equids that survive recurrent disease episodes progress to the inapparent stage of disease where no clinical signs are evident; however, there is persistent, ongoing virus replication. Lentiviruses exist within the host as ...


The Role Of Rev-Sr Protein Interactions In The Regulation Of Equine Infectious Anemia Virus Replication , Gregory Saang Park Jan 2003

The Role Of Rev-Sr Protein Interactions In The Regulation Of Equine Infectious Anemia Virus Replication , Gregory Saang Park

Retrospective Theses and Dissertations

Equine infectious anemia virus (EIAV) is a member of the lentivirus subfamily of retroviruses that produces a variable clinical disease course characterized as acute, chronic, and inapparent. The clinical signs can vary according to the stage of disease, and generally correlate with levels of virus replication. As with other retroviruses, EIAV utilizes both RNA and proteins to produce alternatively spliced transcripts required for virus replication. EIAV encodes a protein called Rev, which functions by binding unspliced and singly spliced viral mRNAs in the nucleus at a sequence called the Rev responsive element (RRE) and exporting them into the cytoplasm. Rev ...