Articles 1 - 1 of 1
Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Primary Photoprocesses Of Light-Activated Antiviral And Antitumor Agents, Hypericin And Hypocrellin , Alexandre V. Smirnov
Retrospective Theses and Dissertations
The dissertation focuses on the ultrafast primary photoprocesses of the title anti-viral and anti-cancer agents, whose activity depends on light which is also accompanied by photoacidification in vesicles and living cells;By complementing the techniques of time-resolved absorption spectroscopy with those of fluorescence upconversion and applying them to hypericin, hypocrellin A and B, and their methylated analogs that are unable to execute proton transfer, it was demonstrated that intramolecular excited-state hydrogen atom transfer is a dominant primary nonradiative process;For hypocrellin A in viscous solvents such as octanol and ethylene glycol, an absorption transient of ∼10-ps duration, similar to the ...