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Biochemistry, Biophysics, and Structural Biology Commons

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Retrospective Theses and Dissertations

1994

Veterinary Pathology and Pathobiology

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Molecular Characterization Of Porcine Respiratory Coronavirus Isolates With Varying Pathogenicity , Eric Martin Vaughn Jan 1994

Molecular Characterization Of Porcine Respiratory Coronavirus Isolates With Varying Pathogenicity , Eric Martin Vaughn

Retrospective Theses and Dissertations

Three new isolates of porcine respiratory coronavirus (PRCV) were isolated and characterized. Two of the PRCV isolates, AR310 and LEPP, were shown to produce moderate interstitial pneumonia, whereas the third PRCV isolate, IA1894, was only mildly pathogenic in five-week-old specific pathogen free pigs. The previously described PRCV isolate ISU-1, a mildly pathogenic PRCV isolate, was also included in this study. These PRCV isolates with varying pathogenicity provided an opportunity to determine if there are certain genes that correlate with virulence, as the genes 3 and 3-1 have been hypothesized to be virulence determinants for transmissible gastroenteritis virus (TGEV) isolates. Using ...