Open Access. Powered by Scholars. Published by Universities.®

Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Retrospective Theses and Dissertations

Physical Sciences and Mathematics

Organic

Publication Year

Articles 1 - 2 of 2

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Cooperative Binding By A Self-Assembled Receptor: Metal In A Structural And Functional Role , Jin-Ho Lee Jan 1994

Cooperative Binding By A Self-Assembled Receptor: Metal In A Structural And Functional Role , Jin-Ho Lee

Retrospective Theses and Dissertations

Metal complexes of the amino acid, 4,4[superscript]'-phosphinylidine bis phenylalanine (PBP*, 1), self-assemble to produce a macrocyclic receptor (Co[subscript]2PBP[subscript]2, 2) with a hydrophobic cavity capable of binding aromatic compounds from water. Here we demonstrate that the metal can play a structural and a functional role: the receptor binds substrates bearing both aromatic and polar functional groups ditopically, using the hydrophobic pocket as well as the metal itself. The doubly anionic Co[superscript]2+ macrocyclic complex binds neutral aromatic guests more tightly than it does most anionic guests, as would be expected. However, carboxylates tethered ...


Synthesis Of Some Valine Derivatives As Potential Antibacterial Agents , Frederick Nelson Minard Jan 1949

Synthesis Of Some Valine Derivatives As Potential Antibacterial Agents , Frederick Nelson Minard

Retrospective Theses and Dissertations

No abstract provided.