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Retrospective Theses and Dissertations

Physical Sciences and Mathematics

Inorganic chemistry

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Multifunctional Mesoporous Silica Nanospheres For Biosensor, Stimuli-Responsive Controlled-Release Drug Delivery Carriers And Gene Transfection Vectors , Cheng-Yu Lai Jan 2004

Multifunctional Mesoporous Silica Nanospheres For Biosensor, Stimuli-Responsive Controlled-Release Drug Delivery Carriers And Gene Transfection Vectors , Cheng-Yu Lai

Retrospective Theses and Dissertations

Structurally well-defined mesoporous silica materials with tunable pore size and narrow pore-size distribution have attracted much attention for their potential applications in sensing, drug delivery and gene transfer. A series of mesoporous silica nanosphere-based (MSN) nano-devices were synthesized and utilized for the aforementioned applications.;For sensing application, we provide a first example in utilization of a multi-functionalized mesoporous silica material to selectively detect dopamine. A second application, rooted in this work, is the selective detection of amino-containing neurotransmitters under physiological condition.;The drug delivery applications have been built around a controlled release drug delivery device. In the original conception, the ...


Interactions And Electron-Transfer Reactions Between Metalloproteins , Milan Miroslav Crnogorac Jan 2000

Interactions And Electron-Transfer Reactions Between Metalloproteins , Milan Miroslav Crnogorac

Retrospective Theses and Dissertations

Electron-transfer reactions are essential for life. Because metalloproteins are involved in electron transport in the cell, it is important to understand the factors that affect recognition, interaction, and reactions of these electron carriers. Cytochrome c is well-characterized electron-carrier protein. The heme protein cytochrome c and the blue-copper protein plastocyanin are well suited for kinetic and mechanistic studies since their structures are known in detail;We investigated the effects of site-directed mutations and viscosity on rate-limiting rearrangement within the complex of cytochrome c and plastocyanin and identified the reactive configuration of the complex. In the reactive configuration of the complex cytochrome ...


Selective Labeling Of Peptides, Metalloproteins, And Proteolytic Enzymes With Pt(Ii) Complexes And Electron-Transfer Reactions Of Native And Cross-Linked Metalloproteins , Herb M. Brothers Ii Jan 1991

Selective Labeling Of Peptides, Metalloproteins, And Proteolytic Enzymes With Pt(Ii) Complexes And Electron-Transfer Reactions Of Native And Cross-Linked Metalloproteins , Herb M. Brothers Ii

Retrospective Theses and Dissertations

The transition-metal complex (Pt(trpy)Cl) [superscript]+ selectively labels the amino acids Cys and His, but is unreactive toward Met. The (Pt(trpy)Cl) [superscript]+ complex also forms complexes with nonbiological ligands to form novel compounds with metal-metal or [pi]-[pi] interactions;The homologous gold reagent, (Au(trpy)Cl) [superscript]2+ reacts with Trp, Cys, His, and Met. The oxidative properties of the gold complex makes it an invasive reagent toward proteins, however;In reactions with proteins, the complex (Pt(trpy)Cl) [superscript]+ exhibits unexpected selectivity toward amino acid side chains in cytochromes c. His residues are labeled in greater ...