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Biochemistry, Biophysics, and Structural Biology Commons

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Retrospective Theses and Dissertations

Physical Sciences and Mathematics

2001

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Photophysics And Light Induced Photobiology Of Antiviral And Antitumor Agents, Hypericin And Hypocrellin , Jaehun Park Jan 2001

Photophysics And Light Induced Photobiology Of Antiviral And Antitumor Agents, Hypericin And Hypocrellin , Jaehun Park

Retrospective Theses and Dissertations

The dissertation mainly focuses on the excited-state photophysics and the light-induced biological activity of hypericin and its analogs.;Femtosecond laser technology has provided the opportunity to investigate the rapid dynamics of these molecules. Fluorescence upconversion measurements, which monitor only emission from the fluorescent singlet state, demonstrate that hexamethoxy hypericin, which possesses no labile protons, has an instantaneous rise time for its transient response. On the other hand, hypericin shows a clear 10-ps rise time. This confirms excited-state H-atom transfer as the primary photophysical process in hypericin.;Femtosecond transient absorption spectroscopy technique is used to determine if excited state H-atom transfer ...