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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Molecular Basis Of Campylobacter Antibiotic Resistance And Adaptation To The Intestinal Tract Of Chickens, Baoqing Guo
Retrospective Theses and Dissertations
Campylobacter is a major foodborne pathogen causing human enteric infections. Antibiotic treatments are needed for prolonged and severe cases of campylobacteriosis, but Campylobacter is increasingly resistant to antimicrobials, which has rendered antimicrobial therapy less effective. Multiple mechanisms contribute to antibiotic resistance in Campylobacter, but antibiotic efflux mediated by membrane transporters is considered a significant player in conferring intrinsic and acquired resistance to a broad spectrum of antimicrobials. The recently published genomic sequence revealed the presence of multiple genes encoding efflux transporters in C. jejuni, and work conducted in our laboratory identified that CmeABC, a RND (resistance nodulation and cell division ...