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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Molecular Basis Of Campylobacter Antibiotic Resistance And Adaptation To The Intestinal Tract Of Chickens, Baoqing Guo Jan 2007

Molecular Basis Of Campylobacter Antibiotic Resistance And Adaptation To The Intestinal Tract Of Chickens, Baoqing Guo

Retrospective Theses and Dissertations

Campylobacter is a major foodborne pathogen causing human enteric infections. Antibiotic treatments are needed for prolonged and severe cases of campylobacteriosis, but Campylobacter is increasingly resistant to antimicrobials, which has rendered antimicrobial therapy less effective. Multiple mechanisms contribute to antibiotic resistance in Campylobacter, but antibiotic efflux mediated by membrane transporters is considered a significant player in conferring intrinsic and acquired resistance to a broad spectrum of antimicrobials. The recently published genomic sequence revealed the presence of multiple genes encoding efflux transporters in C. jejuni, and work conducted in our laboratory identified that CmeABC, a RND (resistance nodulation and cell division ...


Biotechnological Improvements Of Bio-Based Fuels And Lubricants: Characterization Of Genes For Branched Chain Fatty Acids And Mono-Acyl Esters, Yuqin Jin Jan 2007

Biotechnological Improvements Of Bio-Based Fuels And Lubricants: Characterization Of Genes For Branched Chain Fatty Acids And Mono-Acyl Esters, Yuqin Jin

Retrospective Theses and Dissertations

The goals of the research in this dissertation are to generate the fundamental technologies that can be used to improve the production and quality of vegetable-oil based biodiesel and biolubricants. Specifically, we sought to test the hypothesis that branched chain fatty acids (BCFAs) can substitute for unsaturated fatty acids in maintaining fluidityin an organism. Toward this goal, we examined the utility of two Bacillus keto-acyl synthase III (KASIII) coding genes (yhfB and yjaX) in producing BCFAs. In conducting this research it was necessary to examine if the E. coli KASIII gene (fabH) was essential for initiating fatty acid biosynthesis and ...


Methanobactin And The Membrane-Associated Methane Monooxygenase In Methanotrophy: A Tale Of Two Proteins, Dongwon Choi Jan 2007

Methanobactin And The Membrane-Associated Methane Monooxygenase In Methanotrophy: A Tale Of Two Proteins, Dongwon Choi

Retrospective Theses and Dissertations

No abstract provided.