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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Modification Of Chromium(Vi)-Induced Dna Damage By Glutathione And Cytochromes P-450 In Chicken Embryo Hepatocytes., Doreen Y. Cupo, Karen E. Wetterhahn Oct 1985

Modification Of Chromium(Vi)-Induced Dna Damage By Glutathione And Cytochromes P-450 In Chicken Embryo Hepatocytes., Doreen Y. Cupo, Karen E. Wetterhahn

Open Dartmouth: Faculty Open Access Scholarship

The role of glutathione and cytochrome P-450 in the production of DNA damage by chromium(VI) was examined in chicken embryo hepatocytes by the alkaline elution technique. Cellular levels of glutathione and cytochrome P-450 were altered by treating the hepatocytes with N-acetyl-L-cysteine, buthionine sulfoximine, isopentanol, or beta-naphthoflavone. A dramatic increase in chromium(VI)-induced DNA strand breaks was observed after increasing glutathione levels in the cells. Chromium(VI)-induced DNA strand breaks were even more numerous when the level of cytochrome P-450 was also increased. Upon depletion of glutathione levels and induction of cytochrome P-450 or cytochrome P-448, little or ...


Autoregulation Of Collagenase Production By A Protein Synthesized And Secreted By Synovial Fibroblasts: Cellular Mechanism For Control Of Collagen Degradation, Constance Brinckerhoff, Mary Benoit, William Culp Apr 1985

Autoregulation Of Collagenase Production By A Protein Synthesized And Secreted By Synovial Fibroblasts: Cellular Mechanism For Control Of Collagen Degradation, Constance Brinckerhoff, Mary Benoit, William Culp

Open Dartmouth: Faculty Open Access Scholarship

No abstract provided.