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FIU Electronic Theses and Dissertations

Aedes aegypti

Entomology

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Characterization Of Juvenile Hormone Biosynthetic Enzymes In The Mosquito, Aedes Aegypti, Pratik Nyati Nov 2014

Characterization Of Juvenile Hormone Biosynthetic Enzymes In The Mosquito, Aedes Aegypti, Pratik Nyati

FIU Electronic Theses and Dissertations

The juvenile hormones (JHs) are sesquiterpenoid compounds that play a central role in insect reproduction, development and behavior. They are synthesized and secreted by a pair of small endocrine glands, the corpora allata (CA), which are intimately connected to the brain. The enzymes involved in the biosynthesis of JH are attractive targets for the control of mosquito populations. This dissertation is a comprehensive functional study of five Aedes aegypti CA enzymes, HMG-CoA synthase (AaHMGS), mevalonate kinase (AaMK), phosphomevalonate kinase (AaPMK), farnesyl diphosphate synthase (AaFPPS) and farnesyl pyrophosphate phosphatase (AaFPPase).

The enzyme AaHMGS catalyzes the ...