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Chemistry Faculty Publications

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Articles 151 - 156 of 156

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Synthesis Of Phosphatidyl Peptides I. O-(Distearoyl-L-A-Glycerylphosphoryl)-L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke (From The Banting And Best Department Of Medical Research, University Of Toronto, Toronto, Canada), Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd Jan 1957

Synthesis Of Phosphatidyl Peptides I. O-(Distearoyl-L-A-Glycerylphosphoryl)-L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke (From The Banting And Best Department Of Medical Research, University Of Toronto, Toronto, Canada), Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd

Chemistry Faculty Publications

The synthesis of a phosphatidyl tripeptide has been accomplished. It was prepared by (a) phosphorylation of D-α,β-distearin with phenylphosphoryl dichloride and pyridine, (b) esterification of the resulting distearoylL- α-glycerylphenylphosphoryl chloride with N-carbobenzoxy-L-serylglycylglycine benzyl ester in the presence of lutidine, and (c) removal of the protective groups by catalytic hydrogenolysis. The O-( distearoyl-L-α-glycerylphosphoryl)- L-serylglycylglycine was obtained in an over-all yield of 12 per cent. The synthesis of N-carbobenzoxy-L-serylglycylglycine benzyl ester, for which two procedures have been reported, has been simplified considerably by condensing N -carbobenzoxy-L-serine with glycylglycine benzyl ester by means of N ,N' -dicyclohexylcarbodiimide. The phosphatidyl tripeptide is cleaved ...


L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke, Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd Jan 1956

L-Serylglycylglycine / By Erich Baer, Jonas Maurukas, And Donald D. Clarke, Erich Baer, Jonas Maurukas, Donald Dudley Clarke Phd

Chemistry Faculty Publications

A synthesis of the hitherto unreported L-serylglycylglycine by two different methods is described. N-carbobenzoxy L-serylglycylglycine benzyl ester, an intermediate in the preparation of the tripeptide, was found to be a suitable derivative in the synthesis of L-α-phosphatidyl L-serylglycylglycine


Ultraviolet Absorption Spectra Of Derivatives Of 2,3,5- And 2,4,5-Trihydroxyacetophenone / By D. D. Clarke And F. F. Nord, Donald Dudley Clarke Phd, Friedrich F. Nord Jan 1955

Ultraviolet Absorption Spectra Of Derivatives Of 2,3,5- And 2,4,5-Trihydroxyacetophenone / By D. D. Clarke And F. F. Nord, Donald Dudley Clarke Phd, Friedrich F. Nord

Chemistry Faculty Publications

No abstract provided.


Radicinin: A Metabolite From Stemphylium Radicinum. Ii. On The Mechanism Of Its Biosynthesis / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord Jan 1955

Radicinin: A Metabolite From Stemphylium Radicinum. Ii. On The Mechanism Of Its Biosynthesis / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord

Chemistry Faculty Publications

After studying the effect of various substrates and also of certain enzyme inhibitors on the rate of formation of radicinin by Sterad, it is suggested that the carbohydrate molecule is utilized intact in the biosynthesis of radicinin


Radicinin: A Metabolite From Stemphylium Radicinum. I. Chemistry And Action / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord Jan 1955

Radicinin: A Metabolite From Stemphylium Radicinum. I. Chemistry And Action / D. D. Clarke And F. F. Nord From The Department Of Organic Chemistry And Enzymology, Fordham University, New York, New York, Donald Dudley Clarke Phd, Friedrich F. Nord

Chemistry Faculty Publications

The conditions for the growth of Sterad and isolation of radicinin are described. The formula C12H1205 wasas established for this compound by preparation and analyses of several derivatives. Degradation and spectrophotometric studies were employed to establish the molecular formula. Studies on the mode of action of radicinin revealed that it caused an increase in the rate of dehydrogenation of isopropyl alcohol by FIB, but that it had no effect on the quantity or degree of desaturation of the fat synthesized by FIB


Radicinin: A New Pigment From Stemphylium Radicinum / D. D. Clarke F. F. Nord Department Of Organic Chemistry And Enzymology, Fordham University, New York 58, New York, Donald Dudley Clarke Phd, Friedrich F. Nord Jan 1953

Radicinin: A New Pigment From Stemphylium Radicinum / D. D. Clarke F. F. Nord Department Of Organic Chemistry And Enzymology, Fordham University, New York 58, New York, Donald Dudley Clarke Phd, Friedrich F. Nord

Chemistry Faculty Publications

No abstract provided.