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Biochemistry, Biophysics, and Structural Biology Commons

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Chemistry Faculty Publications

Fordham University

1995

Articles 1 - 2 of 2

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Substituted 8-Quinolinols: Halo, Nitro, And Sulfonic Acids / Herman Gershon, Donald D. Clarke, And Muriel Gershon Department Of Chemistry, Fordham University, Bronx, New York 10458 U.S.A., New York Botanical Garden, Bronx, New York 10458, U.S.A., Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon Jan 1995

Substituted 8-Quinolinols: Halo, Nitro, And Sulfonic Acids / Herman Gershon, Donald D. Clarke, And Muriel Gershon Department Of Chemistry, Fordham University, Bronx, New York 10458 U.S.A., New York Botanical Garden, Bronx, New York 10458, U.S.A., Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon

Chemistry Faculty Publications

Methods have been systematized for preparing substituted 8-quinolinols. The 5 and 7 positions are those available for electrophilic substitution. The entry position of the electrophile can be controlled by controlling the prototropic form of the 8-quinolinol. Under acidic conditions the 5 position is attacked first and under basic conditions the electrophile is directed to the 7 position. Iodination is the reverse. Regiospecificity also can be achieved by blocking the 5 or 7 position with sulfonic acid groups followed by addition of the electrophile and deblocking by acid hydrolysis, providing the new substituent is stable to acid hydrolysis. When compounds containing ...


Antifungal Activity Of Halophenols And Halonitrophenols / H. Gershon, D. D. Clarke, And M. Gershon Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa New York Botanical Garden, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon Jan 1995

Antifungal Activity Of Halophenols And Halonitrophenols / H. Gershon, D. D. Clarke, And M. Gershon Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa New York Botanical Garden, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd, Muriel Gershon

Chemistry Faculty Publications

Thirty one compounds (phenol; its 12 possible monohalo analogues; 18 nitrophenols (2- and 4-nitrophenols, 4-, 5-, and 6-halo-2-nitrophenols, 3-halo-4-nitrophenols)) were tested for antifungal activity against six fungi (A. niger, A. oryzae, M. verrucaria, T. viride, M. cirinelloides, and T. mentagrophytes) in Sabouraud dextrose broth. The two most fungitoxic compounds of those studied were 5-fluoro- and 5-iodo-2-nitrophenols which inhibited all the fungi at concentrations under 10 μg/ml. 6-Iodo-2-nitrophenol inhibited five fungi at a concentration below 10 μg/ml and M. cirinelloides at 10- 100 μg/ ml