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Biochemistry, Biophysics, and Structural Biology Commons

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Glial Cells And Metabolic Compartmentation / S. Berl, W.J. Nicklas, And D.D. Clarke Dept. Of Neurology, Mt. Sinai School Of Medicine, N.Y., N.Y. 10029 Dept. Of Chemistry, Fordham University, N.Y. 10458, U.S.A., Soll Berl, William J. Nicklas, Donald Dudley Clarke Phd Jan 1978

Glial Cells And Metabolic Compartmentation / S. Berl, W.J. Nicklas, And D.D. Clarke Dept. Of Neurology, Mt. Sinai School Of Medicine, N.Y., N.Y. 10029 Dept. Of Chemistry, Fordham University, N.Y. 10458, U.S.A., Soll Berl, William J. Nicklas, Donald Dudley Clarke Phd

Chemistry Faculty Publications

The study of metabolic compartmentation in brain has been under investigation for some twenty years. Most interpretations of the data have focused on attempts to assess the relative contributions of glia and neurons to the metabolic pictures since anatomically and functionally they are distinct. It is very probable that these cell types contain other metabolic compartments based on anatomic and subcellular subdivisions. However, the presently available experimental data is insufficient to specify precisely the total number of such metabolic pools functioning in nervous tissue. The initial observations that set in motion most of the work were a) in the adult ...


Amino Acid Analogs Iv: 4-Fluoroisoleucine / Herman Gershon, Larry Shanks, And Donald D. Clark, Herman Gershon, Larry Shanks, Donald Dudley Clarke Phd Jan 1978

Amino Acid Analogs Iv: 4-Fluoroisoleucine / Herman Gershon, Larry Shanks, And Donald D. Clark, Herman Gershon, Larry Shanks, Donald Dudley Clarke Phd

Chemistry Faculty Publications

4-Fluoroisoleucine was produced by ammonolysis of 2- bromo-4-fluoro-3-methylpentanoic acid, which resulted from the bromofluorination of 4-methyl-2-pentenoic acid. It did not inhibit Plasmodium berghei in mice at 640 mg/kg and was not toxic to the animals. The fluoroamino acid inhibited Aspergillus niger, Trichoderma viride, Myrothecium verrucaria, Trichophyton mentagrophytes, and Mucor mucedo in Czapek solution agar at a concentration between 104 and 103 μg/ml. Growth of Escherichia coli was inhibited 25% at 900 μg/ml in a defined medium