Open Access. Powered by Scholars. Published by Universities.®

Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Chemistry Faculty Publications

Fordham University

1974

Articles 1 - 2 of 2

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Interaction Of Catecholamine And Amino Acid Metabolism In Brain: Effect Of Pargyline And L-Dopa / W. J. Nicklas, S. Berl, And D. D. Clarke Department Of Neurology, College Of Physicians And Surgeons, Columbia University, 640 West 168th Street, New York, Ny 10032 And Department Of Chemistry, Fordham University, Bronx, Ny 10458, U.S.A., Soll Berl, William J. Nicklas, Donald Dudley Clarke Phd Jan 1974

Interaction Of Catecholamine And Amino Acid Metabolism In Brain: Effect Of Pargyline And L-Dopa / W. J. Nicklas, S. Berl, And D. D. Clarke Department Of Neurology, College Of Physicians And Surgeons, Columbia University, 640 West 168th Street, New York, Ny 10032 And Department Of Chemistry, Fordham University, Bronx, Ny 10458, U.S.A., Soll Berl, William J. Nicklas, Donald Dudley Clarke Phd

Chemistry Faculty Publications

The combination of L-DOPA and pargyline caused a decrease in level of aspartate and an increase in that of glutamine in vivo in cerebral cortex, cerebellum, brain stem, hypothalamus, neostriatum and cervical cord of rat. There was also a decreased incorporation of radioactivity from [1-14C]acetate into amino acids in rico, most notably in cerebellum and brain stem. The labelling of glutamine was especially affected. In addition, cortical slices were prepared from guinea pigs which had been pretreated with pargyline. These slices were incubated with and without 1 mM L-DOPA in media containing [l- 14C]acetate. Pargyline alone caused a ...


Isolation And Stereochemical Identification Of A Metabolite Of Naltrexone From Human Urine / Nithiananda Chatterjie, James M. Fujimoto, Charles E. Inturrisi, Sandra Reorig, Richard I.H. Wang, David V. Bowen, Frank H. Field, And Donald D. Clarke Department Of Pharmacology, Cornell University Medical College (N.C., C.E.I.), Department Of Pharmacology, Medical College Of Wisconsin (J.M.F., S.R.), Veterans Administrative Center, Wood, Wisconsin (R.I.H.W.), Mass Spectrometry Service Laboratory, The Rockefeller University (D.V.B., F.H.F.), And Department Of Chemistry, Fordham University (D.D.C.), Nithiananda Chatterjie, James M. Fujimoto, Charles E. Inturrisi, Donald Dudley Clarke Phd Jan 1974

Isolation And Stereochemical Identification Of A Metabolite Of Naltrexone From Human Urine / Nithiananda Chatterjie, James M. Fujimoto, Charles E. Inturrisi, Sandra Reorig, Richard I.H. Wang, David V. Bowen, Frank H. Field, And Donald D. Clarke Department Of Pharmacology, Cornell University Medical College (N.C., C.E.I.), Department Of Pharmacology, Medical College Of Wisconsin (J.M.F., S.R.), Veterans Administrative Center, Wood, Wisconsin (R.I.H.W.), Mass Spectrometry Service Laboratory, The Rockefeller University (D.V.B., F.H.F.), And Department Of Chemistry, Fordham University (D.D.C.), Nithiananda Chatterjie, James M. Fujimoto, Charles E. Inturrisi, Donald Dudley Clarke Phd

Chemistry Faculty Publications

Pooled urine samples from patients receiving 100-200 mg of naltrexone per day orally were extracted; the basic (alkaloid) compounds derived were isolated by preparative thin-layer chromatography. The major metabolite of naltrexone was found to be an epimer of N-cyclopropylmethyl- 14-hydroxy-7,8-dihydronormorphine wherein the 6-keto group of naltrexone had been reduced to yield the 6β-hydroxy epimer (an isomorphine). This conclusion was based on infrared, mass, and nuclear magnetic resonance spectra studies. Furthermore, the reduction product formed in vitro in a soluble chicken liver enzyme system from naltrexone and an in vivo metabolite of naloxone derived from the chicken were found to ...