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Biochemistry, Biophysics, and Structural Biology Commons

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Chemistry Faculty Publications

Biochemistry

Monochloro-8-quinolinols

Publication Year

Articles 1 - 2 of 2

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Synergistic Mixtures Of Fungitoxic Monochloro And Dichloro-8-Quinolinols Against Five Fungi / Herman Gershon, Muriel Gershon, & Donald D. Clarke Harding Laboratory, The New York Botanical Garden, Bronx, Ny 10458-5126, Usa; Department Of Chemistry, Fordham University, Bronx, Ny 10458-9993, Usa, Herman Gershon, Muriel Gershon, Donald Dudley Clarke Phd Jan 2004

Synergistic Mixtures Of Fungitoxic Monochloro And Dichloro-8-Quinolinols Against Five Fungi / Herman Gershon, Muriel Gershon, & Donald D. Clarke Harding Laboratory, The New York Botanical Garden, Bronx, Ny 10458-5126, Usa; Department Of Chemistry, Fordham University, Bronx, Ny 10458-9993, Usa, Herman Gershon, Muriel Gershon, Donald Dudley Clarke Phd

Chemistry Faculty Publications

Fourteen mono- and dichloro-8-quinolinols were tested against five fungi (Aspergillus niger, A. oryzae, Myrothecium verrucaria, Trichoderma viride, and Mucor circinelloides) and compared with the fungitoxicity of 8- quinolinol in Yeast Nitrogen Base containing l% D-glucose and 0.088% L-asparagine. All of the compounds were more fungitoxic than 8-quinolinol except for the surprising activity of 8-quinolinol against A. oryzae. Mixtures of the MICs of monochloro- and dichloro-8-quinolinols in which the halogens were in different positions of the quinoline ring showed synergism. Comparable mixtures in which one position of each compound was occupied by the same halogen showed additive activity. In a ...


Improved Syntheses Of Some Monochloro- And Monobromo-8-Quinolinols / Herman Gershon And Donald D. Clarke Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd Jan 1991

Improved Syntheses Of Some Monochloro- And Monobromo-8-Quinolinols / Herman Gershon And Donald D. Clarke Department Of Chemistry, Fordham University, Bronx, Ny 10458, Usa, Herman Gershon, Donald Dudley Clarke Phd

Chemistry Faculty Publications

Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz 1H-NMR spectra for the 12 possible monochloro and mono bromo analogues are given