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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

The Texas Medical Center Library

2012

Clostridium quorum sensing

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Regulation Of Toxin Synthesis By Clostridium Difficile, Charles Darkoh Aug 2012

Regulation Of Toxin Synthesis By Clostridium Difficile, Charles Darkoh

UT GSBS Dissertations and Theses (Open Access)

Clostridium difficile is the leading definable cause of nosocomial diarrhea worldwide due to its virulence, multi-drug resistance, spore-forming ability, and environmental persistence. The incidence of C. difficile infection (CDI) has been increasing exponentially in the last decade. Virulent strains of C. difficile produce either toxin A and/or toxin B, which are essential for the pathogenesis of this bacterium. Current methods for diagnosing CDI are mostly qualitative tests that detect the bacterium, the toxins, or the toxin genes. These methods do not differentiate virulent C. difficile strains that produce active toxins from non-virulent strains that do not produce toxins or ...