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Biochemistry, Biophysics, and Structural Biology Commons

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Articles 1 - 5 of 5

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Acute And Chronic Cadmium Exposure Promotes E-Cadherin Degradation In Mcf7 Breast Cancer Cells, Esmeralda Ponce, Maggie Louie, Mary B. Sevigny Sep 2015

Acute And Chronic Cadmium Exposure Promotes E-Cadherin Degradation In Mcf7 Breast Cancer Cells, Esmeralda Ponce, Maggie Louie, Mary B. Sevigny

Maggie Louie

Cadmium is an environmental carcinogen that usually enters the body at minute concentrations through diet or cigarette smoke and bioaccumulates in soft tissues. In past studies, cadmium has been shown to contribute to the development of more aggressive cancer phenotypes including increased cell migration and invasion. This study aims to determine if cadmium exposure-both acute and chronic-contributes to breast cancer progression by interfering with the normal functional relationship between E-cadherin and β-catenin. An MCF7 breast cancer cell line (MCF7-Cd) chronically exposed to 10(-7)  M CdCl2 was previously developed and used as a model system to study chronic exposures, whereas ...


Chronic Cadmium Exposure Promotes Breast Cancer Progression, Maggie Louie Sep 2012

Chronic Cadmium Exposure Promotes Breast Cancer Progression, Maggie Louie

Maggie Louie

No abstract available


Cadmium As An Estrogen Receptor Modulator, Maggie Louie May 2011

Cadmium As An Estrogen Receptor Modulator, Maggie Louie

Maggie Louie

No abstract available


The Effects Of Cadmium On Breast Cancer Progression, Maggie Louie Oct 2010

The Effects Of Cadmium On Breast Cancer Progression, Maggie Louie

Maggie Louie

No abstract available


Gene Expression In Cadmium-Tolerant Datura Innoxia: Detection And Characterization Of Cdnas Induced In Response To Cd2+, Maggie Louie, Nathan Kondor, Jane G. Dewitt Apr 2003

Gene Expression In Cadmium-Tolerant Datura Innoxia: Detection And Characterization Of Cdnas Induced In Response To Cd2+, Maggie Louie, Nathan Kondor, Jane G. Dewitt

Maggie Louie

The response of a metal tolerant plant to heavy metal stress involves a number of biochemical pathways. To investigate the overall molecular response of a metal-tolerant plant to heavy-metal exposure, suppressive subtractive hybridization was used to create a library enriched in cadmium-induced cDNAs from cadmium-tolerant Datura innoxia. Two differential screening steps were used to screen the cadmium-induced library resulting in 8 putative cadmium-specific cDNAs out of a pool of 94 clones. Reverse transcriptase polymerase chain reaction was used to confirm that 4 of these 8 clones were cadmium-specific, while the other 4 were induced under heat shock or in the ...