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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

None

2009

Estrogen

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Signal Pathway Of 17Β-Estradiol–Induced Muc5b Expression In Human Airway Epithelial Cells, H Choi, Y Chung, H Kim, U Moon, Y Choi, I Van Seuringen, Seung Baek, H Yoon, J Yoon Dec 2008

Signal Pathway Of 17Β-Estradiol–Induced Muc5b Expression In Human Airway Epithelial Cells, H Choi, Y Chung, H Kim, U Moon, Y Choi, I Van Seuringen, Seung Baek, H Yoon, J Yoon

Seung J Baek

MUC5B is a major mucin of the human respiratory tract, and it is not clear how MUC5B expression is regulated in various airway diseases. The goal of this study was to determine the mechanisms by which 17β-estradiol induces MUC5B gene expression in airway epithelial cells. It was found that E2, a sex hormone, stimulates MUC5B gene overexpression by interaction with estrogen receptor {alpha} (ER{alpha}) and by acting through extracellular signal–regulated kinase 1/2 (ERK1/2)-mitogen-activated protein kinase (MAPK). Pretreatment with ER antagonist ICI 182,780 blocked both E2-induced ERK1/2-MAPK activation and MUC5B gene expression. It was ...