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Biochemistry, Biophysics, and Structural Biology Commons

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Articles 1 - 5 of 5

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Photodynamic Therapy Of Murine Fibrosarcoma With Topical And Systemic Administration Of Hypericin, I Cavarga, P Brezani, Maria Cekanova, P Solar, P Fedorocko, P Miskovsky Aug 2001

Photodynamic Therapy Of Murine Fibrosarcoma With Topical And Systemic Administration Of Hypericin, I Cavarga, P Brezani, Maria Cekanova, P Solar, P Fedorocko, P Miskovsky

Maria Cekanova MS, RNDr, PhD

The in vivo antitumour activity of the natural photosensitizer hypericin was evaluated. C3H/DiSn mice inoculated with fibrosarcoma G5:1:13 cells were intraperitoneally or intratumourally injected with hypericin (5 mg/kg) and 2 hours later the mice were locally irradiated with laser light (488 nm, 150 mW/cm2, 180 J/cm2) when the tumour reached volume of 40-80 mm3 (approximately 17 days after inoculation). Tumours treated with hypericin alone as well as those irradiated with laser light alone have similar growth rates and none of these tumours regressed spontaneously. The mean tumour volume in hypericin-PDT treated groups was significantly ...


The Evolutionary Significance Of Unihemispheric Slow Wave Sleep In Birds, Charles Amlaner Apr 2001

The Evolutionary Significance Of Unihemispheric Slow Wave Sleep In Birds, Charles Amlaner

Charles J. Amlaner

No abstract provided.


Sleep-Wake Behavior Patterns And Eye Closure States In Juvenile Greater Rheas (Rhea Americana), Charles Amlaner, William Franklin, Christopher Ritzi, Steven Lima, Niels Rattenborg Apr 2001

Sleep-Wake Behavior Patterns And Eye Closure States In Juvenile Greater Rheas (Rhea Americana), Charles Amlaner, William Franklin, Christopher Ritzi, Steven Lima, Niels Rattenborg

Charles J. Amlaner

No abstract provided.


Pyrene Labeled Poly(Aryl Ether) Monodendrons: Synthesis, Characterization, Diffusion Coefficients, And Photophysical Studies, James Hanson, Jeanne Riley, Sibel Alkan, Wajiha Khan, Wyatt Murphy, Aidi Chen, Michael Shapiro Dec 2000

Pyrene Labeled Poly(Aryl Ether) Monodendrons: Synthesis, Characterization, Diffusion Coefficients, And Photophysical Studies, James Hanson, Jeanne Riley, Sibel Alkan, Wajiha Khan, Wyatt Murphy, Aidi Chen, Michael Shapiro

Wyatt Murphy

Four generations of poly(aryl ether) monodendrons labeled with pyrene at the focus were synthesized and characterized by a combination of NMR, size-exclusion chromatography with light scattering detection (SEC-LS), and electronic spectroscopy. The monodendrons were then studied by magnetic resonance and fluorescence techniques. Translational diffusion coefficients in THF-d8, acetonitrile-d3, and cyclohexane-d12 were measured by Pulsed-Field-Gradient NMR and ranged from 2.2 x 10-5 cm2/sec for methoxypyrene in acetonitrile to 3.4 x 10-6 cm2/sec for the fourth generation monodendron in THF. Molecular radii were calculated from the diffusion coefficients by the Stokes-Einstein equation. In THF, the radii increased ...


Abnormal Expression Of P27kip1 Protein In Levator Ani Muscle Of Aging Women With Pelvic Floor Disorders - A Relationship To The Cellular Differentiation And Degeneration., A Bukovsky, P Copas, M Caudle, Maria Cekanova, T Dassanayake, B Asbury, S Vanmeter, R Elder, J Brown, S Cross Dec 2000

Abnormal Expression Of P27kip1 Protein In Levator Ani Muscle Of Aging Women With Pelvic Floor Disorders - A Relationship To The Cellular Differentiation And Degeneration., A Bukovsky, P Copas, M Caudle, Maria Cekanova, T Dassanayake, B Asbury, S Vanmeter, R Elder, J Brown, S Cross

Maria Cekanova MS, RNDr, PhD

BACKGROUND: Pelvic floor disorders affect almost 50% of aging women. An important role in the pelvic floor support belongs to the levator ani muscle. The p27/kip1 (p27) protein, multifunctional cyclin-dependent kinase inhibitor, shows changing expression in differentiating skeletal muscle cells during development, and relatively high levels of p27 RNA were detected in the normal human skeletal muscles. METHODS: Biopsy samples of levator ani muscle were obtained from 22 symptomatic patients with stress urinary incontinence, pelvic organ prolapse, and overlaps (age range 38-74), and nine asymptomatic women (age 31-49). Cryostat sections were investigated for p27 protein expression and type I ...