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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Multiple Mechanisms Are Involved In 6-Gingerol-Induced Cell Growth Arrest And Apoptosis In Human Colorectal Cancer Cells, Seong Lee, Maria Cekanova, Seung Baek Oct 2010

Multiple Mechanisms Are Involved In 6-Gingerol-Induced Cell Growth Arrest And Apoptosis In Human Colorectal Cancer Cells, Seong Lee, Maria Cekanova, Seung Baek

Maria Cekanova MS, RNDr, PhD

6-Gingerol, a natural product of ginger, has been known to possess anti-tumorigenic and pro-apoptotic activities. However, the mechanisms by which it prevents cancer are not well understood in human colorectal cancer. Cyclin D1 is a proto-oncogene that is overexpressed in many cancers and plays a role in cell proliferation through activation by beta-catenin signaling. Nonsteroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) is a cytokine associated with pro-apoptotic and anti-tumorigenic properties. In the present study, we examined whether 6-gingerol influences cyclin D1 and NAG-1 expression and determined the mechanisms by which 6-gingerol affects the growth of human colorectal cancer cells in ...


Epigallocatechin-3-Gallate Inhibits Interleukin-1beta-Induced Muc5ac Gene Expression And Muc5ac Secretion In Normal Human Nasal Epithelial Cells, H Kim, S Park, S Park, U Moon, B Lee, S Yoon, J Lee, Seung Baek, J Yoon Jul 2008

Epigallocatechin-3-Gallate Inhibits Interleukin-1beta-Induced Muc5ac Gene Expression And Muc5ac Secretion In Normal Human Nasal Epithelial Cells, H Kim, S Park, S Park, U Moon, B Lee, S Yoon, J Lee, Seung Baek, J Yoon

Seung J Baek

It has been reported that the proinflammatory cytokine interleukin-1beta (IL-1beta) induces mucus hypersecretion in normal human nasal epithelial (NHNE) cells and that the MAP kinase pathway may be an important signal pathway in IL-1beta-induced MUC5AC gene expression. Green tea (Camellia sinensis) polyphenols are potent anti-inflammatory agents and have been shown to inhibit inflammation in tumor cell lines and cultured respiratory epithelial cells. In this study, we examined the effect of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, on IL-1beta-induced MUC5AC gene expression and secretion in NHNE cells. After cells had been treated with IL-1beta (10 ng/ml) and pretreated with EGCG ...


A Green Tea Component Suppresses Posttranslational Expression Of Basic Fibroblast Growth Factor In Colorectal Cancer, M Sukthanka, K Yamaguchi, Sh Lee, Michael Mcentee, T Eling, Y Hara, Seung Baek May 2008

A Green Tea Component Suppresses Posttranslational Expression Of Basic Fibroblast Growth Factor In Colorectal Cancer, M Sukthanka, K Yamaguchi, Sh Lee, Michael Mcentee, T Eling, Y Hara, Seung Baek

Seung J Baek

BACKGROUND & AIMS: Green tea catechins are known to have anticarcinogenic effects. Epigallocatechin-3-gallate (EGCG) accounts for almost 50% of the total catechin content in green tea extract and has very potent antioxidant effects. EGCG also inhibits angiogenesis, possibly through the inhibition of proangiogenic factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), which in turn, inhibits tumor growth and metastasis. However, the exact molecular mechanism by which EGCG suppresses bFGF expression is not known. Our objective was to elucidate the molecular mechanisms by which EGCG inhibits bFGF expression in colorectal cancer. METHODS: We examined posttranslational regulation of ...