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Physiology

Superoxide dismutase

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Molecular Phylogenetic Evidence For An Extracellular Cu Zn Superoxide Dismutase Gene In Insects, Joel D. Parker Jan 2004

Molecular Phylogenetic Evidence For An Extracellular Cu Zn Superoxide Dismutase Gene In Insects, Joel D. Parker

Joel D Parker

Representatives of three ancient gene families of the antioxidant enzyme superoxide dismutase (SOD) can be found in most metazoans. In mammals and Caenorhabditis elegans , there is at least one gene each of the cytoplasmic, mitochondrial and extracellular lineages of SOD genes. The cytoplasmic SOD was one of the first enzymes to be implicated in ageing due to its protection against damaging oxygen free radicals. In contrast to other metazoans, insects were thought to lack a gene for the extracellular SOD. We have cloned and sequenced an SOD mRNA in the ant Lasius niger that appears to belong to this extracellular ...