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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Physiology

Insulin

2015

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Role Of Protein Kinase Map4k4 In Energy Metabolism: A Dissertation, Laura V. Danai Apr 2015

Role Of Protein Kinase Map4k4 In Energy Metabolism: A Dissertation, Laura V. Danai

GSBS Dissertations and Theses

Systemic glucose regulation is essential for human survival as low or chronically high glucose levels can be detrimental to the health of an individual. Glucose levels are highly regulated via inter-organ communication networks that alter metabolic function to maintain euglycemia. For example, when nutrient levels are low, pancreatic α-cells secrete glucagon, which signals to the liver to promote glycogen breakdown and glucose production. In times of excess nutrient intake, pancreatic β-cells release insulin. Insulin signals to the liver to suppress hepatic glucose production, and signals to the adipose tissue and the skeletal muscle to take up excess glucose via insulin-regulated ...