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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Physiology

2007

Series

AP1

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Suppression Of P53-Dependent Senescence By The Jnk Signal Transduction Pathway, Madhumita Das, Feng Jiang, Hayla Karen Sluss, Chao Zhang, Kevan M. Shokat, Richard A. Flavell, Roger J. Davis Oct 2007

Suppression Of P53-Dependent Senescence By The Jnk Signal Transduction Pathway, Madhumita Das, Feng Jiang, Hayla Karen Sluss, Chao Zhang, Kevan M. Shokat, Richard A. Flavell, Roger J. Davis

Open Access Articles

The JNK signaling pathway is implicated in the regulation of the AP1 transcription factor and cell proliferation. Here, we examine the role of JNK by using conditional and chemical genetic alleles of the ubiquitously expressed murine genes that encode the isoforms JNK1 and JNK2. Our analysis demonstrates that JNK is not essential for proliferation. However, JNK is required for expression of the cJun and JunD components of the AP1 transcription factor, and JNK-deficient cells exhibit early p53-dependent senescence. These data demonstrate that JNK can act as a negative regulator of the p53 tumor suppressor.