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Biochemistry, Biophysics, and Structural Biology Commons

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Physiology

Wright State University

VGLUT1

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Vglut And Gad65 Expression In Physiologically Characterized Ia Afferents, Ivonne Nkoli Ukpabi Jan 2007

Vglut And Gad65 Expression In Physiologically Characterized Ia Afferents, Ivonne Nkoli Ukpabi

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Peripheral nerve injury is known to induce several changes in the physiology and morphology of the injured afferent. These changes include hyperexcitability, decreased dorsal root potentials (DRP), loss of synaptic vesicles as well as loss of the vesicular glutamate transporter, VGLUT1. While many of the changes caused by peripheral injury revert with regeneration, others appear to be permanent. The loss of the stretch reflex for example is a puzzling outcome of recovery after peripheral nerve transection and regeneration, especially given that the electrical counterpart of the stretch reflex (the H-reflex) recovers after regeneration. We hypothesized that stretch induced transmission is ...