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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Is Hif-1Α Required For V-Atpase-Dependent Regulation Of Glycolytic Enzymes?, Tyler Northrup Apr 2016

Is Hif-1Α Required For V-Atpase-Dependent Regulation Of Glycolytic Enzymes?, Tyler Northrup

Life and Environmental Sciences Undergraduate Theses

Vacuolar-ATPase (V-ATPase) is frequently up-regulated in tumors and tumor cell lines where it contributes to tumorigenic phenotypes, including the Warburg Effect (e.g. the phenomenon where glycolysis is preferred over oxidative phosphorylation (Vander Heiden et al. 2009)). The preferential use of glycolytic metabolism favored by tumor cells may be caused by at least two factors (Vander Heiden et al. 2009). First, the metabolic intermediates generated by the citric acid (TCA) cycle are used in a variety of anabolic pathways in the cell, and may supply a ready source of intermediate buildingblocks for biosynthetic processes. Second, hypoxia observed in some tumors ...


Kidney Stones And The Zip10 Transporter: An Analysis Of Calcium Oxalate Stone Formation Using Frog And Fruit Fly Models, Paige Williams Apr 2014

Kidney Stones And The Zip10 Transporter: An Analysis Of Calcium Oxalate Stone Formation Using Frog And Fruit Fly Models, Paige Williams

Life and Environmental Sciences Undergraduate Theses

Kidney stones are a health ailment (~1% population occurrence), yet the mechanism and initiation of stone formation remains incompletely explained. Calcium oxalate (CaOx) stones seem to initially form on sites called Randall’s Plaques that are high in zinc content. A suggested correlation between stone disease and the Zip10 transporter in a GWAS (genome wide association study) on Miniature Schnauzers allowed me to investigate the role of zinc and Zip10 on CaOx stone formation. Our results from radioactive 63Zn uptakes in injected frog (Xenopus laevis) oocytes indicate that (human, canine and Drosophila) Zip10 transport Zn2+. The Zip10 clones had highest ...


The Effects Of Estradiol And Progresterone On The Media Collateral Ligament Of Prepubescent Rats, Nicolle Kahl Apr 2000

The Effects Of Estradiol And Progresterone On The Media Collateral Ligament Of Prepubescent Rats, Nicolle Kahl

Life and Environmental Sciences Undergraduate Theses

Recent studies of female athletes have shown that females are more prone to knee injuries than their male counterparts. This phenomenon has been attributed to several factors including anatomical structure differences such as quadriceps-hamstring imbalances, type of activity (specifically cutting and planting motions), use of braces, and hormonal differences. It is known that hormones like relaxin have an obvious effect on ligament composition, but the effects of other hormones on ligaments has yet to be fully determined. One particular study reported that a female is most susceptible to knee injuries during the pre-ovulatory phase of her cycle, when estrogen levels ...


In Vitro Study Of The Effect Of Hypothermia On The Dissociation Curve Of Blood, Matthew Munding Apr 1992

In Vitro Study Of The Effect Of Hypothermia On The Dissociation Curve Of Blood, Matthew Munding

Life and Environmental Sciences Undergraduate Theses

The aim of this study was to examine the change in the dissociation curve of oxygen from human hemoglobin at the temperatures of 37°, 25°, 18°, 12°, 7°, and 3° C. The partial pressures of oxygen and the calculated hemoglobin saturations were determined for samples at the various temperatures. From this data the partial pressures at 75% saturation were calculated, and the differences in the partial pressures at 75% saturation were compared. The dissociation curve was shown to shift to the left as the temperature was decreased down to 12°. Below 12°, the shift was not further observed. At the ...


The Effects Of Adrenalectomy On The Rat Electrocardiogram, Daniel Murphy Ii Apr 1972

The Effects Of Adrenalectomy On The Rat Electrocardiogram, Daniel Murphy Ii

Life and Environmental Sciences Undergraduate Theses

This thesis is intended to serve several functions. One purpose is to acquaint the writer with the biological systems that have been studied over the past four years. It is also intended to study the correlation between biological systems. This is necessary since much complexity is involved. A study of this nature, then, would bring to light many of the tangential courses studied such as chemistry, statistics, philosophy, and literature. The paper Itself proceeds in two halves. The first half is concerned with research. This gained its impetus when the author was first presented with a monograph on aldosterone. Interest ...


The Effects Of 3-Methylcholanthrene On Humoral Antibodies And On Antibody-Producing Cells In The Spleen, Chris Erickson Apr 1972

The Effects Of 3-Methylcholanthrene On Humoral Antibodies And On Antibody-Producing Cells In The Spleen, Chris Erickson

Life and Environmental Sciences Undergraduate Theses

An increasing number of reports during the Dast decade have suggested a positive, though far from perfect, correlation between carcinogenicity and the ability of a side variety of carcinogens to impair the immune status of the host. In addition, those conditions resulting in the suppression of the immune reaction of the host, including the use of immunosuppressive drugs with transplant patients, seem to foster the incidence of cancer [St jernsward, 1969]. Burnet [1961] has suggested that the evolutionary significance of the immune response is that it enables the elimination of mutant somatic cells, which might otherwise form neoplasms. Then, possibly ...