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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology

2011

University of Massachusetts - Amherst

Alejandro P. Heuck

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

The Sv40 Late Protein Vp4 Is A Viroporin That Forms Pores To Disrupt Membranes For Viral Release, Smita Raghava, Kristen Giorda, F. Romano, Alejandro Heuck, Daniel Hebert Jan 2011

The Sv40 Late Protein Vp4 Is A Viroporin That Forms Pores To Disrupt Membranes For Viral Release, Smita Raghava, Kristen Giorda, F. Romano, Alejandro Heuck, Daniel Hebert

Alejandro P. Heuck

Nonenveloped viruses are generally released by the timely lysis of the host cell by a poorly understood process. For the nonenveloped virus SV40, virions assemble in the nucleus and then must be released from the host cell without being encapsulated by cellular membranes. This process appears to involve the well-controlled insertion of viral proteins into host cellular membranes rendering them permeable to large molecules. VP4 is a newly identified SV40 gene product that is expressed at late times during the viral life cycle that corresponds to the time of cell lysis. To investigate the role of this late expressed protein ...