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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Small Rna-Amino Acid Interactions And Implications For The Origin Of Translation, Rebecca Marie Turk Jan 2010

Small Rna-Amino Acid Interactions And Implications For The Origin Of Translation, Rebecca Marie Turk

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Ribonucleic acid (RNA) has the ability to store and transfer genetic information, and also to catalyze chemical reactions. This observation has led to the RNA world hypothesis, which states that there was likely a time in early evolution (before DNA and proteins) in which RNA carried out both these functions. In particular, RNA may have played an important role in the origin of protein (peptide) synthesis, or translation. While modern protein synthesis requires protein catalysis or stabilization at each of the relevant chemical steps, RNA is the functional heart of the ribosome. There must have been a mechanism in place ...


Cationic Antimicrobial Peptides And Their Mode Of Action: A Genomics Approach For A Better Understanding, Eileen Colie Spindler Jan 2010

Cationic Antimicrobial Peptides And Their Mode Of Action: A Genomics Approach For A Better Understanding, Eileen Colie Spindler

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

Antimicrobial peptides (AMPs) produced from naturally occurring peptides have recently become a focus for drug design. These synthetic derivatives are relatively small (6-12 amino acids), potent, not easily resisted, and active against a broad-range of pathogens; making such compounds particularly attractive as platforms for the development of novel antimicrobials. However, the mode of action of these synthetic peptides, as well as many naturally occurring peptides, remains largely uncharacterized. This lack of understanding, and more specifically the absence of detailed knowledge of the complexity of AMP mode(s) of action, continues to limit our capabilities for taking full advantage of these ...


Rna Processing Events Affecting C. Elegans Operons: A Computational And Mutational Analysis, Mary Ann Allen Jan 2010

Rna Processing Events Affecting C. Elegans Operons: A Computational And Mutational Analysis, Mary Ann Allen

Molecular, Cellular, and Developmental Biology Graduate Theses & Dissertations

In C. elegans, the combined actions of trans-splicing, 3’ end formation and inhibition of transcription termination by RNA polymerase II (Pol II) are necessary to generate monocistronic transcripts from primary polycistronic transcripts. However, how these processes are regulated to create functional monocistronic units out of polycistronic transcripts is poorly understood.

From a global perspective, certain transcripts are trans-spliced to either SL1, SL2 or both. The genes encoding SL1 trans-spliced transcripts have longer distances between the trans-splice site and the nearest upstream gene, and also have evidence of promoters adjacent to the trans-splice sites. The converse is true for genes encoding ...