Open Access. Powered by Scholars. Published by Universities.®

Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology

2009

Series

Davis Lab Publications

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Nuclear Localization Of P38 Mapk In Response To Dna Damage, C. David Wood, Tina Thornton, Guadalupe Sabio, Roger J. Davis, Mercedes Rincon Jun 2009

Nuclear Localization Of P38 Mapk In Response To Dna Damage, C. David Wood, Tina Thornton, Guadalupe Sabio, Roger J. Davis, Mercedes Rincon

Davis Lab Publications

p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cycle checkpoints. The intracellular localization of p38 MAPK upon activation remains unclear, and may depend on the stimulus. We show here that activation of p38 MAPK by stimuli that induce DNA double strand breaks (DSBs), but not other stimuli, leads to its nuclear translocation. In addition, naturally occurring DSBs generated through V(D)J recombination in immature thymocytes also promote nuclear accumulation of p38 MAPK. Nuclear translocation of p38 MAPK does not require its catalytic activity, but is ...