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Articles 1 - 6 of 6

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Retinoic Acid Glucuronide Preparations For Application To The Skin, Arun B. Barua, Desiree Gunning, James A. Olson Dec 1991

Retinoic Acid Glucuronide Preparations For Application To The Skin, Arun B. Barua, Desiree Gunning, James A. Olson

Iowa State University Patents

A method and preparation are described for treating human skin with retinoic acid glucuronide (RAG) in a topical carrier. For treatment of acne or wrinkled skin, RAG can be applied in an effective amount which is nonirritating to the skin. Retinoid dermatitis, an objectionable side effect of topical application of retinoid compounds, can thereby be avoided.


Apparatus And Method For Transient Thermal Infrared Emission Spectrometry, John F. Mcclelland, Roger W. Jones Dec 1991

Apparatus And Method For Transient Thermal Infrared Emission Spectrometry, John F. Mcclelland, Roger W. Jones

Iowa State University Patents

A method and apparatus for enabling analysis of a solid material (16, 42) by applying energy from an energy source (20, 70) top a surface region of the solid material sufficient to cause transient heating in a thin surface layer portion of the solid material (16, 42) so as to enable transient thermal emission of infrared radiation from the thin surface layer portion, and by detecting with a spectrometer/detector (28, 58) substantially only the transient thermal emission of infrared radiation from the thin surface layer portion of the solid material. The detected transient thermal emission of infrared radiation is ...


Apparatus And Method For Transient Thermal Infrared Spectrometry, John F. Mcclelland, Roger W. Jones Dec 1991

Apparatus And Method For Transient Thermal Infrared Spectrometry, John F. Mcclelland, Roger W. Jones

Iowa State University Patents

A method and apparatus for enabling analysis of a material (16, 42) by applying a cooling medium (20, 54) to cool a thin surface layer portion of the material and to transiently generate a temperature differential between the thin surface layer portion and the lower portion of the material sufficient to alter the thermal infrared emission spectrum of the material from the black-body thermal infrared emission spectrum of the material. The altered thermal infrared emission spectrum of the material is detected by a spectrometer/detector (28, 50) while the altered thermal infrared emission spectrum is sufficiently free of self-absorption by ...


Non-Teratogenic Vitamin A Preparation For Women Of Child-Bearing Age, Arun B. Barua, Desiree Gunning, James A. Olson Oct 1991

Non-Teratogenic Vitamin A Preparation For Women Of Child-Bearing Age, Arun B. Barua, Desiree Gunning, James A. Olson

Iowa State University Patents

For treatment of acne the glucuronide of retinoic acid (retinoyl β-glucuronide) is orally administered to women of child-bearing age who are capable of conception. This therapy is safer than the oral administration of retinoic acid because retinoic acid glucuronide is essentially non-teratogenic at dose levels effective for the acne treatment. The retinoic acid glucuronide can be in all-trans or 13-cis form.


Er Translocation Intermediates Are Adjacent To A Nonglycosylated 34-Kd Integral Membrane Protein, Kennan V. Kellaris, Sharon Bowen, Reid Gilmore Jul 1991

Er Translocation Intermediates Are Adjacent To A Nonglycosylated 34-Kd Integral Membrane Protein, Kennan V. Kellaris, Sharon Bowen, Reid Gilmore

Open Access Articles

We have used the homobifunctional cross-linking reagent disuccinimidyl suberate (DSS) to identify proteins that are adjacent to nascent polypeptides undergoing translocations across mammalian rough ER. Translocation intermediates were assembled by supplementing cell free translations of truncated mRNAs with the signal recognition particle (SRP) and microsomal membrane vesicles. Two prominent cross-linked products of 45 and 64 kD were detected. The 64-kD product was obtained when the cell free translation contained SRP, while formation of the 45-kD product required both SRP and translocation competent microsomal membrane vesicles. In agreement with previous investigators, we suggest that the 64-kD product arises by cross-linking of ...


Cell Surface-Binding Sites For Progesterone Mediate Calcium Uptake In Human Sperm, Peter F. Blackmore, Joseph Neulan, Frank Lattanzio, Stephen J. Beebe Jan 1991

Cell Surface-Binding Sites For Progesterone Mediate Calcium Uptake In Human Sperm, Peter F. Blackmore, Joseph Neulan, Frank Lattanzio, Stephen J. Beebe

Bioelectrics Publications

Recent studies (e.g. Blackmore, P. F., Beebe, S. J., Danforth, D. R., and Alexander, N.) (1990) J. Biol. Chem. 265, 1376-1380) have shown that in human sperm, progesterone produces a rapid increase in intracellular free calcium ([Ca2+]i) and an induction of the acrosome reaction (e.g. Osman, R. A., Andria, M. L., Jones, A. D., and Meizel, S. (1989) Biochem. Biophys. Res. Commun. 160, 828-833). In this study, the location of progesterone receptors on the cell surface of human sperm was identified using progesterone immobilized on bovine serum albumin (BSA) (progesterone 3-(O-carboxymethyl)oxime:BSA) as well as ...