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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology
Identification Of Laminin Domains That Promote Tumor Cell Adhesion, Corby Freitag
Life and Environmental Sciences Undergraduate Theses
The process of metastasis requires tumor cells to migrate through the basement membrane which consists of laminin, a glycoprotein which promotes the adhesion of HT-1080 fibrosarcoma cells. The present study was designed to test four peptides, corresponding to short sequences of the intact laminin molecule, for cell adhesion-promoting activity. By using three different cell migration assays, the four peptides were monitored for their cell adhesive-promoting activity. Results were obtained showing some cell adhesive-promoting activity from all four peptides.