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Biochemistry, Biophysics, and Structural Biology Commons

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Molecular Biology

Series

Biomolecular Research Center Publications and Presentations

2014

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

A Lipid-Rich Gestational Diet Predisposes Offspring To Nonalcoholic Fatty Liver Disease: A Potential Sequence Of Events, Alexandria N. Hughes, Julia Thom Oxford Mar 2014

A Lipid-Rich Gestational Diet Predisposes Offspring To Nonalcoholic Fatty Liver Disease: A Potential Sequence Of Events, Alexandria N. Hughes, Julia Thom Oxford

Biomolecular Research Center Publications and Presentations

Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. It affects 20%–30% of the US population, and it is increasing worldwide. Recently, the role of lipid-rich maternal gestational nutrition in spurring the development of NAFLD among offspring has been indicated. Fetal predisposition to NAFLD involves numerous physiological reroutings that are initiated by increased delivery of nonesterified fatty acids to the fetal liver. Hampered ß-oxidation, uncontrolled oxidative stress, increased triacylglycerol synthesis, and the endoplasmic reticulum unfolded protein response are all implicated in sculpting a hepatic phenotype with a propensity to develop NAFLD in the postnatal state. This ...