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Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Molecular Biology

Series

University of Connecticut

2009

Dictyostelium

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

The Role Of Raf Kinase Inhibitor Protein In Cell Motility, Kathryn Grive May 2009

The Role Of Raf Kinase Inhibitor Protein In Cell Motility, Kathryn Grive

Honors Scholar Theses

Raf Kinase Inhibitor Protein (RKIP) has been identified as a phosphatidylethanolamine-binding protein capable of inhibiting Raf-1 kinase, an enzyme significant in cell proliferation and cancer development. When properly functioning, RKIP can mediate the expression of Raf-1 kinase and help prevent uncontrolled cell division. RKIP also has suggested, but unclear, roles in spindle fiber formation during mitosis, regulation of apoptosis, and cell motility. The Fenteany laboratory in the Chemistry Department identified a new small molecule, named Locostatin, as a cell migration inhibitor in mammalian cells, with RKIP as its primary molecular target.

Dictyostelium discoideum possess two RKIP proteins, RKIP-A and RKIP-B ...