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Biochemistry, Biophysics, and Structural Biology Commons

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Molecular Biology

Theses and Dissertations

University of Iowa

2006

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Post Transcriptional Regulation Of Cyclin E During The Embryonic Development Of Xenopus Laevis, Michael Keith Slevin Jan 2006

Post Transcriptional Regulation Of Cyclin E During The Embryonic Development Of Xenopus Laevis, Michael Keith Slevin

Theses and Dissertations

The embryonic cell cycle of Xenopus laevis consists of rapid oscillations between S and M phase occurring in the absence of gap phases and their associated regulatory checkpoints. The end of the 12th cell cycle marks the onset of the midblastula transition (MBT) when the cell cycle lengthens establishing gap phases, their associated checkpoint pathways, and the initiation of zygotic transcription.

During cell cycles 2-12, cyclins A and B are translated and expressed once per cell cycle until the MBT when their protein levels decrease due to a newly transcribed zygotic factor that leads to the deadenylation and subsequent loss ...