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Biochemistry, Biophysics, and Structural Biology Commons

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Molecular Biology

Honors Theses

Amblyomma Maculatum

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Painless Hematophagy: The Functional Role Of Novel Tick Metalloproteases In Pain Suppression, Joseph W. Jelinski May 2016

Painless Hematophagy: The Functional Role Of Novel Tick Metalloproteases In Pain Suppression, Joseph W. Jelinski

Honors Theses

Ticks secrete a plethora of pharmacologically active molecules in their saliva while feeding. These allow the tick to feed upon a host over prolonged periods of time in an itch free and painless attachment. The exact mechanism of pain suppression by the tick has barely been investigated. In this study, two angiotensin converting enzymes (ACEs), members of the metalloprotease family, are identified as potentially responsible for the degradation of pro-inflammatory peptides. It is hypothesized that these tick ACEs block the function of bradykinin through degradation of the peptide, contributing to the tick’s ability to conduct a pain and itch-free ...