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Biochemistry, Biophysics, and Structural Biology Commons

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Cancer Biology

Royal College of Surgeons in Ireland

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Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Mirna-124-3p Reduces Cell Viability In Cisplatin Resistant Neuroblastoma Cell Models., John Christopher Nolan Jul 2017

Mirna-124-3p Reduces Cell Viability In Cisplatin Resistant Neuroblastoma Cell Models., John Christopher Nolan

PhD theses

Neuroblastoma is a highly heterogeneous disease, responsible for 15 % of paediatric cancer deaths. Acquired drug resistance is a major obstacle in high risk neuroblastoma, making the elucidation of mechanisms in development and modulation of drug resistance essential.

Three drug-resistant models, KellyCis83, CHP212Cis100 and SK-N-ASCis24 were developed previously to elucidate mechanisms involved in cisplatin resistance development.

Cisplatin resistance induces phenotypic changes in neuroblastoma. The aim of this work was to characterise phenotypic and proteomic changes and validate a miRNA capable of regulating the expression of up-regulated genes from proteomic analysis of cisplatin resistant sub-lines.

Proteomic profiling was carried out on the ...


Bcl2 Family Proteins Interactions As Prognostic Marker And Determinants Of Therapy Responses In Breast Cancer, Federico Lucantoni Jan 2017

Bcl2 Family Proteins Interactions As Prognostic Marker And Determinants Of Therapy Responses In Breast Cancer, Federico Lucantoni

PhD theses

Triple negative breast cancer (TNBC) is an aggressive form of breast cancer, which accounts for 15-20% of this disease and is currently treated with genotoxic chemotherapy. The BCL2 (B-cell lymphoma 2) family of proteins controls the process of Mitochondrial Outer Membrane Permeabilization (MOMP), which is required for the activation of the mitochondrial apoptosis pathway in response to genotoxic agents. We previously developed a deterministic systems model of BCL2 protein interactions, DR_MOMP that calculates the sensitivity of cells to undergo mitochondrial apoptosis. Here, we determined whether DR_MOMP predicts responses of TNBC cells to genotoxic agents and the re-sensitization of resistant cells ...