Open Access. Powered by Scholars. Published by Universities.®

Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 4 of 4

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Regulation Of Liver Mitochondrial Metabolism During Hibernation By Post-Translational Modification, Katherine E. Mathers Dec 2017

Regulation Of Liver Mitochondrial Metabolism During Hibernation By Post-Translational Modification, Katherine E. Mathers

Electronic Thesis and Dissertation Repository

Hibernation, characterized by a seasonal reduction in metabolism and body temperature, allows animals to conserve energy when environmental conditions (e.g. temperature, food availability) are unfavourable. During hibernation, small mammals such as the 13-lined ground squirrel (Ictidomys tridecemlineatus) cycle between two distinct metabolic states: torpor, where metabolic rate is suppressed by >95% and body temperature falls to ~5 °C, and interbout euthermia (IBE), where metabolic rate and body temperature rapidly increase and are maintained at euthermic levels several hours. Suppression of metabolism during entrance into torpor is paralleled by rapid suppression of liver mitochondrial metabolism. In my thesis, I aimed ...


Liver And Skeletal Muscle Mitochondria Proteomes Are Altered In Pigs Divergently Selected For Residual Feed Intake, Judson Kyle Grubbs, Elisabeth J. Huff-Lonergan, Nicholas K. Gabler, Jack C. Dekkers, Steven M. Lonergan Jan 2014

Liver And Skeletal Muscle Mitochondria Proteomes Are Altered In Pigs Divergently Selected For Residual Feed Intake, Judson Kyle Grubbs, Elisabeth J. Huff-Lonergan, Nicholas K. Gabler, Jack C. Dekkers, Steven M. Lonergan

Animal Science Publications

Animals selected for residual feed intake (RFI) can be used as a model to elucidate molecular explanations for differences in growth efficiency. The objective of this study was to determine the extent to which the protein profile and posttranslational modifications of mitochondria from skeletal muscle and liver relate to feed efficiency gains in pigs divergently selected for RFI. Mitochondria were isolated from the longissimus dorsi (LD) muscle and the liver from pigs (n = 9 each for the high and low RFI line; BW = 95.8 kg). Mitochondria protein profile differences were determined using two-dimensional difference in gel electrophoresis. Proteins were ...


Bioengineered Lysozyme Reduces Bacterial Burden And Inflammation In A Murine Model Of Mucoid Pseudomonas Aeruginosa Lung Infection, Charlotte C. Teneback, Thomas C. Scanlon, Matthew J. Wargo, Jenna L. Bement, Karl E. Griswold, Laurie W. Leclair Aug 2013

Bioengineered Lysozyme Reduces Bacterial Burden And Inflammation In A Murine Model Of Mucoid Pseudomonas Aeruginosa Lung Infection, Charlotte C. Teneback, Thomas C. Scanlon, Matthew J. Wargo, Jenna L. Bement, Karl E. Griswold, Laurie W. Leclair

Open Dartmouth: Faculty Open Access Scholarship

The spread of drug-resistant bacterial pathogens is a growing global concern and has prompted an effort to explore potential adjuvant and alternative therapies derived from nature's repertoire of bactericidal proteins and peptides. In humans, the airway surface liquid layer is a rich source of antibiotics, and lysozyme represents one of the most abundant and effective antimicrobial components of airway secretions. Human lysozyme is active against both Gram-positive and Gram-negative bacteria, ac


Dihydroxyphenylalanine Metabolism By Kidney Tissue , Robert Edward Clegg Jan 1948

Dihydroxyphenylalanine Metabolism By Kidney Tissue , Robert Edward Clegg

Retrospective Theses and Dissertations

No abstract provided.