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Articles 1 - 3 of 3

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

The Biopolitics Of The Border, Etienne S. Benson Jan 2014

The Biopolitics Of The Border, Etienne S. Benson

Departmental Papers (HSS)

First a story about science. In the early decades of the twentieth century, the British ornithologist Henry Eliot Howard made a remarkable discovery. In a series of books culminating in his Territory in Bird Life of 1920, Howard described the instinct for the possession of "territory" that he had found in warblers and other birds. The drive to claim and defend a clearly bordered portion of the landscape, he argued, was the controlling factor in the birds' social life. Among other things, it regulated which males could breed, kept the population in balance with its resources, determined how the birds ...


Unbearable Future, Etienne S. Benson Jan 2013

Unbearable Future, Etienne S. Benson

Departmental Papers (HSS)

“Two research scientists kill five bears” was the headline splashed across the front page of the Tundra Times on April 8, 1966. The perpetrators were Vagn Flyger and Martin Schein, biologists from Maryland who had just spent three weeks on Alaska’s North Slope trying to tranquilize and tag polar bears. According to Flyger and Schein’s own later report, they had in fact accidentally killed only four bears (Flyger 1967: 53). Of the thirty-eight they had pursued by aircraft over the sea ice near Barrow, Alaska, they had managed to hit seven with darts laden with a powerful muscle ...


The Evolution Of Platelet Responses To Collagen Under Conditions Of Hemodynamic Flow, Alec A. Schmaier Aug 2010

The Evolution Of Platelet Responses To Collagen Under Conditions Of Hemodynamic Flow, Alec A. Schmaier

Publicly Accessible Penn Dissertations

Collagen activates platelets through the immune-type GPVI receptor, but the mechanism by which this receptor has adapted to function in platelets under conditions of rapid blood flow is unclear. Additionally, it is unknown if responses to collagen are conserved in nucleated thrombocytes found in non-mammalian vertebrates, which do not express GPVI. Here we show that the GPVI proline-rich domain accelerates GPVI signaling kinetics and is required for maximal adhesion to collagen under flow. The proline-rich domain accelerates signaling through binding and directly activating the Src-family kinase Lyn. Chicken thrombocytes are potently activated by collagen but do not form 3-dimensional aggregates ...