Open Access. Powered by Scholars. Published by Universities.®

Biochemistry, Biophysics, and Structural Biology Commons

Open Access. Powered by Scholars. Published by Universities.®

Animal Sciences

Selected Works

Jonathan Mochel

Articles 1 - 1 of 1

Full-Text Articles in Biochemistry, Biophysics, and Structural Biology

Paper Spray High-Resolution Accurate Mass Spectrometry For Quantitation Of Voriconazole In Equine Tears, Jonathan P. Mochel Apr 2019

Paper Spray High-Resolution Accurate Mass Spectrometry For Quantitation Of Voriconazole In Equine Tears, Jonathan P. Mochel

Jonathan Mochel

Paper spray high-resolution accurate mass spectrometry is a fast and versatile analysis method. This ambient ionization technique enables the quantitation of xenobiotics in complex biological matrices without chromatography or conventional sample extraction. The simplicity, rapidity, and affordability of the paper spray mass spectrometry (PS-MS) method make the technique especially attractive for clinical investigations where fast and affordable sample analysis is crucial. A new PS-MS method for the quantitation of voriconazole in equine tears was developed and validated. For a concentration range of 10 to 1000 ng/mL, good linearity (R2 > 0.99), inter- and intra-run precision (coefficient of variation ...