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Full-Text Articles in Life Sciences

Re-Thinking Alzheimer's Disease Therapeutic Targets Using Gene-Based Tests, Man Ki Kwok, Shi Lin Lin, C Mary Schooling Oct 2018

Re-Thinking Alzheimer's Disease Therapeutic Targets Using Gene-Based Tests, Man Ki Kwok, Shi Lin Lin, C Mary Schooling

Publications and Research

Background: Alzheimer's disease (AD) is a devastating condition with no known effective drug treatments. Existing drugs only alleviate symptoms. Given repeated expensive drug failures, we assessed systematically whether approved and investigational AD drugs are targeting products of genes strongly associated with AD and whether these genes are targeted by existing drugs for other indications which could be re-purposed.

Methods: We identified genes strongly associated with late-onset AD fromthe loci of genetic variants associated with AD at genome-wide-significance and from a gene-based test applied to the most extensively genotyped late-onset AD case (n=17,008)-control (n=37,154) study ...


Dobi Studies, Teaches The Marvels Of Genetics, Aldemaro Romero Jr. Sep 2018

Dobi Studies, Teaches The Marvels Of Genetics, Aldemaro Romero Jr.

Publications and Research

“When I was in third grade, a parent of one of the other students brought a number of cats to the library on a Saturday and talked about how there are all these different hereditary patterns that contribute to their coat colors and appearance, like spots, stripes, and white paws. I was just hooked because I loved cats, and I said this is what I want to do.”

That’s how Dr. Krista Dobi explains why she became a geneticist. A native of North Brunswick, New Jersey, Dobi received a bachelor of arts from Princeton University and a doctorate in ...


Egfr Polymorphisms In Drosophila Melanogaster, Stacie Chue, Neha Mehta, Samantha Poon, Heather Trazino May 2018

Egfr Polymorphisms In Drosophila Melanogaster, Stacie Chue, Neha Mehta, Samantha Poon, Heather Trazino

Publications and Research

No abstract provided.


Transcription Activator Like Effector Nucleases (Talens): A New, Important, And Versatile Gene Editing Technique With A Growing Literature, Philip Barnett Dec 2017

Transcription Activator Like Effector Nucleases (Talens): A New, Important, And Versatile Gene Editing Technique With A Growing Literature, Philip Barnett

Publications and Research

Transcription activator like effector nucleases (TALENs) is a new and powerful technique in genetic engineering that can delete deleterious genes or add beneficial genes to organisms. It is being widely studied to improve crops and livestock, and is also being investigated clinically. Comparing the details of how both TALENs and its competitor, CRISPR-Cas9, function, reveals the potential advantages of TALENs. The growing literature, besides covering the scientific and technical aspects of TALENs, also includes pertinent information on regulatory aspects and the public’s perception and acceptance of TALENs.


Spokony Is A Hands-On Researcher, Teacher Of Genetics., Aldemaro Romero Jr. Jun 2017

Spokony Is A Hands-On Researcher, Teacher Of Genetics., Aldemaro Romero Jr.

Publications and Research

“When I was very little, my parents always took

us to the American Museum of Natural History,

the Bronx Zoo, and then even just watching on TV

we would pick the shows that were about science.”

That is how Dr. Rebecca Spokony traces back her

interest in science.

A native of Brooklyn Heights, New York City,

she remembers how when her mother was an

undergraduate, she worked on fruit flies. “Even

though she did not go on to work on science after

she graduated from college, it still was important

to her, and she shared that with me, and I ...


Siddhartha Mukherjee. The Gene. An Intimate History. New York: Scribner, 2016. 593 Pp. $32.00 Cloth (Isbn 978-1-4767-3350-0), Aldemaro Romero Jr. Dec 2016

Siddhartha Mukherjee. The Gene. An Intimate History. New York: Scribner, 2016. 593 Pp. $32.00 Cloth (Isbn 978-1-4767-3350-0), Aldemaro Romero Jr.

Publications and Research

Heredity has always been, in one form or another, at the center of biological

research. There is little doubt that the first scientific experimentation took place

about fifteen thousand years ago, when humans started breeding plants and

animals in order to domesticate them. Today the science of genetics seems to

advance at such a pace that even the experts have trouble keeping up with all the

developments. Now we are witnessing the expansion of our understanding of this

realm of science to levels unimaginable just a few decades ago.