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2019

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Articles 3301 - 3330 of 4152

Full-Text Articles in Life Sciences

Near-Field Electrospinning Of A Polymer/Bioactive Glass Composite To Fabricate 3d Biomimetic Structures, Krishna C. R. Kolan, Jie Li, Sonya Roberts, Julie A. Semon, Jonghyun Park, D. E. Day, Ming-Chuan Leu Jan 2019

Near-Field Electrospinning Of A Polymer/Bioactive Glass Composite To Fabricate 3d Biomimetic Structures, Krishna C. R. Kolan, Jie Li, Sonya Roberts, Julie A. Semon, Jonghyun Park, D. E. Day, Ming-Chuan Leu

Biological Sciences Faculty Research & Creative Works

Bioactive glasses have recently gained attention in tissue engineering and three-dimensional (3D) bioprinting because of their ability to enhance angiogenesis. Some challenges for developing biological tissues with bioactive glasses include incorporation of glass particles and achieving a 3D architecture mimicking natural tissues. In this study, we investigate the fabrication of scaffolds with a polymer/bioactive glass composite using near-field electrospinning (NFES). An overall controlled 3D scaffold with pores, containing random fibers, is created and aimed to provide superior cell proliferation. Highly angiogenic borate bioactive glass (13-93B3) in 20 wt.% is added to polycaprolactone (PCL) to fabricate scaffolds using the NFES ...


The Potential Use Of Seagrass Herbivory Patterns As An Indicator Of Herbivore Community Change After Tropical Marine Protected Area Establishment, John M. Carroll, Amber D. Stubler, Christopher M. Finelli, Bradley J. Peterson Jan 2019

The Potential Use Of Seagrass Herbivory Patterns As An Indicator Of Herbivore Community Change After Tropical Marine Protected Area Establishment, John M. Carroll, Amber D. Stubler, Christopher M. Finelli, Bradley J. Peterson

Gulf and Caribbean Research

Throughout the Caribbean, fishing pressure has decreased the abundance of many species, including both large predators and larger-bodied herbivores. In an effort to reverse these trends and reduce harvest pressure on vulnerable fish populations, Marine Protected Areas (MPAs) have been established throughout the Caribbean. Yet, the effort to monitor fish communities, is variable, and there are MPAs where no monitoring program exists. It is possible that other metrics may be used to determine whether the impact of MPA establishment. By comparing two seagrass herbivory experiments, one pre- and one post-MPA establishment, we provide evidence that the MPA established in Discovery ...


A Singer’S Stress: Yoga And Meditation Techniques In The Collegiate Voice Studio, Zackery David Morris Jan 2019

A Singer’S Stress: Yoga And Meditation Techniques In The Collegiate Voice Studio, Zackery David Morris

Theses and Dissertations--Music

Often neglected in voice study is the understanding that a singer’s instrument lives in his/her body and therefore cannot be packed away like other musical objects. Yoga and mindfulness compliment the belief of a whole body instrument. Data gathered on college campuses report that stress and anxiety are on the rise, thus reinforcing the need for MBSR and yoga as beneficial and proven tools for stress relief. The current state of research in the realm of mental health in colleges merits the study of a cohesive layout of these exercises and their expected outcomes in singing as well ...


Evolution Of The Zhx Transcription Factor Family And Analysis Of Zhx2 Target Genes Cyp2a4 And Cyp2a5 In Mouse Liver, Alexandra Nichole Nail Jan 2019

Evolution Of The Zhx Transcription Factor Family And Analysis Of Zhx2 Target Genes Cyp2a4 And Cyp2a5 In Mouse Liver, Alexandra Nichole Nail

Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics

The liver is the largest internal organ and performs a wide variety of functions to maintain organismal homeostasis. While some liver functions are carried out by all hepatocytes, other functions are restricted to certain populations of hepatocytes within the liver. This phenomenon, called zonal gene regulation or liver zonation, controls may metabolic processes within the liver including ammonia detoxification; glucose homeostasis; bile acid and glutamine synthesis; and metabolism of xenobiotics, lipids, and amino acids. The liver also expresses many genes in a developmental or sex-biased manner. Some genes are expressed at higher levels early or late in development, or alternatively ...


Ecology, Monogamy, And The Evolution Of Animal Families, Jacqueline Rae Dillard Jan 2019

Ecology, Monogamy, And The Evolution Of Animal Families, Jacqueline Rae Dillard

Theses and Dissertations--Biology

Family-living has been recognized as a necessary prerequisite for the evolution of advanced cooperative societies, yet the evolutionary and ecological processes that drive the coupling of different forms of cooperation in family-based societies are still poorly understood. In my dissertation, I investigate the correlated evolution of parental care, monogamy, and cooperative breeding in a variety of family-based taxa. I explore the mating and social behavior of family-living beetles with incipient cooperation to better understand the factors driving these social traits. Specifically, I evaluate different causes of extra-pair mating in socially monogamous beetles, the potential benefits that young adult offspring may ...


Ultrastructural Analysis Of The Digestive Gland Secretory And Absorptive Processes In Nepenthes Glandulifera, Shannon Manuel Jan 2019

Ultrastructural Analysis Of The Digestive Gland Secretory And Absorptive Processes In Nepenthes Glandulifera, Shannon Manuel

Biochemistry, Cellular and Molecular Biology Honors Papers

Nepenthes glandulifera is a carnivorous pitcher plant native to tropical environments, of which the majority live on the islands in the Malay Archipelago where sunlight and water are abundant. The pitcher trap style contains a modified pitfall trap that attracts insects and other small invertebrates through various attractive mechanisms. These plants also contain digestive glands that secrete digestive fluid to break down prey into nutrients for the plant. The digestive fluid, with remarkably unique properties, has been analyzed in relation to multiple areas of study including the development of an enzyme-supplementation strategy for the treatment of celiac disease and the ...


Lifelines Winter 2019, Southern Adventist University Jan 2019

Lifelines Winter 2019, Southern Adventist University

Lifelines Newsletter

No abstract provided.


Reexamining The Utility Of Existing Climate Adaptation Frameworks Through Application On A Northern Forest, Alexander Rice Jan 2019

Reexamining The Utility Of Existing Climate Adaptation Frameworks Through Application On A Northern Forest, Alexander Rice

Dissertations, Master's Theses and Master's Reports

A review of the literature reveals the strengths and limitations of various climate adaptation frameworks and illuminates a general path by which a type of adaptation can be achieved. A number of useful frameworks exist but the number of independent case studies demonstrating the adaptation process in a detailed manner is much more limited. Additionally, components of the various adaptation processes can often seem vague and concepts such as adaptability ill-defined. For land managers approaching climate adaptation independently can be difficult, particularly in the areas of goal creation and vulnerability assessment. Within frameworks where user-defined adaptation goals dictate whether or ...


Impact Of Industrial Biocides On Bacterial Isolates From Hydraulic Fracturing Produced Water, Waad Ahmed Aljohani Jan 2019

Impact Of Industrial Biocides On Bacterial Isolates From Hydraulic Fracturing Produced Water, Waad Ahmed Aljohani

Dissertations, Master's Theses and Master's Reports

Biocides are antimicrobial compounds that are designed to kill diverse groups of microbes in an untargeted fashion. Glutaraldehyde and DBNPA are commonly used to manage microbial growth in different industries. It is possible that biocide use may result in the development of bacterial resistance. However, resistance to DBNPA is believed to be limited under normal use conditions. We isolated a number of bacteria from produced water from a hydraulically fractured site in West Texas. We then tested the ability of these isolates to resist Glutaraldehyde and DBNPA. In this study, we found that these isolates have varying resistance to these ...


Application Of Short Tandem Target Mimic (Sttm) Technique For Functional Analysis Of Micro-Rna396 In Transgenic Poplar Trees, Surattana Boonsai Jan 2019

Application Of Short Tandem Target Mimic (Sttm) Technique For Functional Analysis Of Micro-Rna396 In Transgenic Poplar Trees, Surattana Boonsai

Dissertations, Master's Theses and Master's Reports

Short Tandem Target Mimic (STTM) is a commonly technique used for functional studies of a number of genes in several plant model systems. However, very little is known about application of STTM technique in tree species. In this study, STTM was applied to knock down microRNA396 (miR396) in transgenic poplar trees for the first time. STTM396 expression resulted in dramatic decrease in miR396 expression levels leading to taller plants with larger leaves and larger leaf cell size. Additionally, an expression analysis of growth regulating factor genes (GRFs) that are members of miR396 target gene family showed up-regulation of GRF07 gene ...


Effects Of Invasive Watermilfoil And Seasonal Dynamics On Primary Production In Littoral Zones Of North-Temperate Lakes, Ryan R. Van Goethem Jan 2019

Effects Of Invasive Watermilfoil And Seasonal Dynamics On Primary Production In Littoral Zones Of North-Temperate Lakes, Ryan R. Van Goethem

Dissertations, Master's Theses and Master's Reports

Climate change and species invasion are two agents of global change altering aquatic ecosystems worldwide. Submerged aquatic macrophytes control lake ecosystem processes through their direct and indirect interactions with other primary producers, but how their interactions may be altered by species invasions or how they function over full seasonal cycles in temperate lakes is poorly understood. We first addressed whether the presence of invasive watermilfoil (IWM) altered standing crops and gross primary pro-duction (GPP) of other littoral primary producers (macrophytes, phytoplankton, attached algae or periphyton) in littoral zones of 6 Michigan lakes. We found no differences in primary producer standing ...


Northern Hardwood Silviculture: Preferences Among Family Forest Owners In The Western Upper Peninsula Of Michigan, Alexander C. Helman Jan 2019

Northern Hardwood Silviculture: Preferences Among Family Forest Owners In The Western Upper Peninsula Of Michigan, Alexander C. Helman

Dissertations, Master's Theses and Master's Reports

In the northern hardwood forests of the Western Upper Peninsula of Michigan, single-tree selection is the most commonly used silvicultural system. This system provides both a sustained yield of timber and attempts to emulate the windfall disturbance regime that determines the uneven aged structure of northern hardwood forests. However, with concerns about tree species diversity loss and a lack of early successional forests, even-aged regeneration methods are likely to become an increasingly crucial tool in the toolbox for managing northern hardwood forests of the Lake States. The forests of the Western Upper Peninsula are comprised of a mosaic of ownerships ...


The Impact Of Household Biocides And Antibiotics On Aquatic Microbial Community Composition, Abdulaziz Saud M Alrashdi Jan 2019

The Impact Of Household Biocides And Antibiotics On Aquatic Microbial Community Composition, Abdulaziz Saud M Alrashdi

Dissertations, Master's Theses and Master's Reports

Triclosan (TCS) is antimicrobial agent that is used in a lot of consumer products, including toothpaste, liquid and bar soap, and cosmetics. TCS has been found in many lakes and rivers in the United States. However, The Food and Drug Administration (FDA) banned TCS recently and it will no longer be used in household products. Despite the recent ban, TCS is known to persist in the environment and may have long-term impacts. We conducted an experiment on using fresh water from three locations Houghton, Green Bay and the Huron Mountains. Our goals in the study is to assess the impact ...


The Orexin System In Doca-Salt Hypertension: Regulation Of Vasopressin, Jeremy Bigalke Jan 2019

The Orexin System In Doca-Salt Hypertension: Regulation Of Vasopressin, Jeremy Bigalke

Dissertations, Master's Theses and Master's Reports

Orexin is a neuropeptide with a large range of functions, with a recently discovered role in blood pressure (BP) regulation. Although the role of brain orexin system in hypertension has been investigated in several hypertensive animals, it remains unclear whether activation of the orexin system contributes to the development of Deoxycorticosterone-acetate (DOCA) hypertension, an animal model of human salt sensitive hypertension. In this study, we investigated the hypothesis that Orexin-1 receptor (OX1R) expression is increased in the paraventricular nucleus (PVN), a critical brain area controlling cardiovascular function, which subsequently increases vasopressin (AVP) expression and peripheral secretion, resulting in hypertension development ...


Exploration Of Hair Cortisol Concentrations And Implications Of Stress In Hunting Dogs On The Bosawas Biosphere Reserve, Nicaragua, Grace Bowland Jan 2019

Exploration Of Hair Cortisol Concentrations And Implications Of Stress In Hunting Dogs On The Bosawas Biosphere Reserve, Nicaragua, Grace Bowland

Undergraduate Honors Theses

This thesis examines the relationships between physiological factors of hair color, sex, nutritional health, and body size (mass) with measures of hair cortisol in domesticated Nicaraguan hunting dogs on the Bosawas Biosphere Reserve. Prior research on cortisol in dogs has been relatively limited to small, homogenous population samples under restricted environmental conditions. This leaves a gap in current knowledge, and a need for larger-scale studies to assess whether current understandings of how cortisol acts in dogs is applicable to dogs within dynamic and heterogeneous environments. The population of hunting dogs examined in this study live in an unpredictable environment in ...


Methods Of Testing Skin Mucosomes Of Anaxyrus Boreas In The Face Of Batrachocytrium Dendrobatidis, Gena Rumsey Jan 2019

Methods Of Testing Skin Mucosomes Of Anaxyrus Boreas In The Face Of Batrachocytrium Dendrobatidis, Gena Rumsey

Undergraduate Honors Theses

The microbial community of amphibians skin has demonstrated significant importance in amphibian health and disease resistance specifically in response to the pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd; Barnhart et al. 2017). Since its discovery in the late 1990s, Bd has contributed to world-wide decline in amphibian populations. Multiple naturally occurring amphibian-skin bacteria have been identified as inhibitors of Bd, including Janthinobacterium lividum (J liv; Harris et al. 2009). The McKenzie group developed a probiotic treatment of J liv as an intervention for a boreal toad population in Colorado drastically declining due to a Bd epidemic. Since wild toads cannot be ...


The Use Of Visualizations In A Biology Classroom At The University Of Colorado At Boulder As An Alternative Way To Access Student Understanding, Katie Ryan Jan 2019

The Use Of Visualizations In A Biology Classroom At The University Of Colorado At Boulder As An Alternative Way To Access Student Understanding, Katie Ryan

Undergraduate Honors Theses

As educational practices start to focus on three-dimensional (3D) learning for students by incorporating practices, concepts, and core ideas, it is vital to understand how alternative forms of idea development affect student understanding. In a revolutionary 2015 commentary, Quillin and Thomas (2015) created the model Drawing-to-Learn to convey the need for drawing in Biology classrooms. The main conclusion was that since other STEM (Science, Technology, Engineering, and Mathematical) disciplines are using drawings to create a deeper understanding of the topic, there is also a need for it in biology. Using similar ideas to the concept of Drawing- to-Learn, 109 students ...


Distance Gradient Of Vocalization Discrimination And Aggression In Neighborhoods Of Rufous-And-White Wrens (Thryophilus Rufalbus), Andrew P. Newgard Jan 2019

Distance Gradient Of Vocalization Discrimination And Aggression In Neighborhoods Of Rufous-And-White Wrens (Thryophilus Rufalbus), Andrew P. Newgard

Undergraduate Honors Theses

Vocalization-based communication networks have been observed in multiple animal taxa. Many territorial animals in these communication networks tend to act differentially towards their neighbors compared to farther-removed strangers given competitive pressure in habitats. My study investigated communication among rufous-and-white wrens (Thryophilus rufalbus), and whether this involves greater aggression towards neighbors or towards strangers. T. rufalbus vocally defend territories year-round and have been shown to exhibit ability to discriminate between vocalizations of neighbors versus strangers (neighbor-stranger discrimination, NSD). I quantified whether T. rufalbus demonstrates different levels of aggression upon hearing played-back vocalizations from close-by neighbors, neighbors of adjacent neighbors, and most ...


Effects Of H-Ras Disease Mutations On Binding To The Ras Binding Domain Of Pi3ky Measured By Micro-Scale Thermophoresis, Justin Martyr Jan 2019

Effects Of H-Ras Disease Mutations On Binding To The Ras Binding Domain Of Pi3ky Measured By Micro-Scale Thermophoresis, Justin Martyr

Undergraduate Honors Theses

H-Ras is a G-protein responsible for the activation of multiple signaling pathways that control cell growth. Our primary interest is examining its role in the regulation of the phosphoinositide-3-kinase (PI3K) signaling cascade, as H-Ras has been previously shown to recruit PI3K to the plasma membrane where this lipid kinase phosphorylates PIP2 to PIP3, a signal for cellular growth. The H-Ras-PI3K-PIP3 signaling pathway is known to be highly oncogenic, with constitutive activation of H-Ras leading to increased PIP3 production and cell growth. We hypothesize that disease-linked mutations on the binding interface between Ras and PI3K increase the ...


Effect Of Quinolizidine Alkaloid Consumption And Seed Feeding Behavior On Caterpillar Growth, Hannah Hartung Jan 2019

Effect Of Quinolizidine Alkaloid Consumption And Seed Feeding Behavior On Caterpillar Growth, Hannah Hartung

Undergraduate Honors Theses

Caterpillars who feed on a wide variety of plant hosts must adapt to the defenses of every plant they feed on. For seed-eating caterpillars this can be particularly difficult because the seed is one of the most heavily defended bodies on a plant. Helicoverpa zea, the corn earworm, is both a seed eater and a generalist, feeding on plants belonging to over 30 families, including both agricultural crops and native plants, such as Lupinus texensis. I studied the corn earworm and L. texensis to answer three questions: i) what is the feeding behavior of these seed-eating caterpillars, ii) how do ...


Using Genetically Encoded Fluorescent Sensors To Accurately Observe The Physiology Of Persister Cells Through Single-Cell Microscopy, Thomas Yao Jan 2019

Using Genetically Encoded Fluorescent Sensors To Accurately Observe The Physiology Of Persister Cells Through Single-Cell Microscopy, Thomas Yao

Undergraduate Honors Theses

Isogenic bacterial communities are capable of harboring a small subpopulation of phenotypically distinguished cells that are transiently resistant to antibiotics. Upon exposure to antibiotics, these cells - termed persisters - enter a dormant state, rendering them tolerant to the antibiotic stimulus. Once the antibiotic stimulus subsides, these cells revert to a normal state and continue dividing to repopulate the community. This feature makes it extremely difficult to eradicate persisters, consolidating their role in the recurrence of chronic infections. While multiple mechanisms can trigger entry into the persistent state, the underlying factor leading to dormancy has been determined to stem from a downregulation ...


The Grass Is Always Greener On The Other Side (Of The Basement Membrane): Prostate Cancer Metastasis As Intracorporeal Dispersal, Matthew Oh Jan 2019

The Grass Is Always Greener On The Other Side (Of The Basement Membrane): Prostate Cancer Metastasis As Intracorporeal Dispersal, Matthew Oh

Undergraduate Honors Theses

Dispersal ecology offers a possible explanation for the behavior of prostate cancer (PCa), which disproportionately metastasizes to the bone. Organisms become more likely to leave their home patch when conditions are unfavorable, with the goal of becoming established in more favorable patches. Similarly, PCa cells are pushed from the prostate tumor by hypoxic stress and pulled toward the bone by the presence of bone stromal cells (BSCs), which support PCa growth and proliferation. When PCa settles in the bone, it leads to the formation of a feedforward loop in which PCa enhances osteoblast differentiation; osteoblasts in turn promote PCa proliferation ...


Quantifying Community Response To Drought: A Trait Based Analysis Of The Xeric Tallgrass Prairie In Boulder, Colorado, Emily Kelman Jan 2019

Quantifying Community Response To Drought: A Trait Based Analysis Of The Xeric Tallgrass Prairie In Boulder, Colorado, Emily Kelman

Undergraduate Honors Theses

Increased severity and duration of drought events in Colorado pose a threat to grassland systems. Utilizing plant traits to analyze community responses to environmental disturbance serves as an accurate mechanism in addressing climate change influences on grassland ecosystems. In this project, I aim to quantify the relationship between five plant traits and drought intensity over time, in order to see if plant traits can capture changes in community structure in response to drought. I calculated the mean value of traits at the community level as well as the amount of variation observed in those values, in order to analyze community ...


Using Random Forest Machine Learning Methods To Identify Spatiotemporal Patterns Of Cheatgrass Invasion Through Landsat Land Cover Classification In The Great Basin From 1984 - 2011, Dylan Murphy Jan 2019

Using Random Forest Machine Learning Methods To Identify Spatiotemporal Patterns Of Cheatgrass Invasion Through Landsat Land Cover Classification In The Great Basin From 1984 - 2011, Dylan Murphy

Undergraduate Honors Theses

In the Great Basin region of the Western United States, the establishment of cheatgrass (Bromus tectorum), an invasive annual grass, has dramatically affected native sagebrush steppe ecosystems. Cheatgrass, and the grass-fire cycle associated with the species, have led to extensive sagebrush community degradation, fragmentation, and eventually, conversion to near-monoculture exotic cheatgrass grasslands. This process has changed regional fire regimes, placing people, property, and native fauna at risk. Despite the known impacts of cheatgrass invasion in the Great Basin, attempts to quantify regional scale changes in ecosystem type have been limited. In this study, a methodology is developed which utilizes Random ...


Benthic Macroinvertebrates In The Alpine Lakes Of Green Lakes Valley, Samuel Yevak Jan 2019

Benthic Macroinvertebrates In The Alpine Lakes Of Green Lakes Valley, Samuel Yevak

Undergraduate Honors Theses

The community composition of different benthicmacroinvertebrates can be used as an indicator of environmental conditions. Benthicmacroinvertebrates are small organisms that lack a backbone (invertebrate), live on the bottom (benthic), and are visible with the naked eye (macro). To better understand the community structure of benthicmacroinvertebrates communities and how they respond to changing environmental conditions, 53 benthic macroinvertebrate samples were collected over the summer of 2018 from three alpine lakes in the Green Lakes Valley, CO. Benthicmacroinvertebrates were sampled from the shoreline, inlet (inflow of water), and outlet (outflow of water) of each sampled lake, within lake ...


The Climb Towards Conservation: Identifying And Mitigating The Effects Of Outdoor Rock Climbing On Surrounding Ecosystems In Colorado, Chloe Sommer Jan 2019

The Climb Towards Conservation: Identifying And Mitigating The Effects Of Outdoor Rock Climbing On Surrounding Ecosystems In Colorado, Chloe Sommer

Undergraduate Honors Theses

Since the 1960s, rock climbing has become an increasingly important player in America’s recreation landscape. Today, rock climbing is a growing contributor to the nation’s $800+ billion-dollar outdoor recreation industry, and indoor and outdoor climbing are more popular than ever. Historically, rock climbers and other outdoor recreationalists have claimed a correlation between recreation and conservation of public lands. Ample evidence suggests, however, that rock climbing still causes an array of negative impacts to ecosystems. This is the first known study to analyze potential impacts of recreational outdoor rock climbing on a large scale with GIS techniques, overlaying geographic ...


Predicting Persisters: Investigating Gene Regulation In Persister Cells, Sowmya Dhanwada Jan 2019

Predicting Persisters: Investigating Gene Regulation In Persister Cells, Sowmya Dhanwada

Undergraduate Honors Theses

Bacterial populations produce a small number of persister cells that remain tolerant to multidrug exposure by becoming metabolically dormant. This inquiry focuses on investigating metabolic gene expression levels in persisters to determine potential predictors of bacterial persistence. Strains from the E. Coli Promoter library were imaged using single cell microscopy, and gene expression levels were measured with the integrated reporter GFP. Persister cells were isolated using ofloxacin. Results indicate that bacterial cells that survive antibiotic exposure exhibit filamentous growth before dividing. Resumption of normal growth morphology is accompanied by increased proteolytic activity in daughter cells, however more investigation is required ...


Developmental And Functional Analysis Of Scutes In The Armored Catfish Corydoras Aeneus, Emily Volk Jan 2019

Developmental And Functional Analysis Of Scutes In The Armored Catfish Corydoras Aeneus, Emily Volk

Undergraduate Honors Theses

Fish scales are specialized biological structures of current interest in innovative materials design because of the combination of protective function, flexibility, and light weight they offer. This study presents a developmental and functional investigation of a particular fish scale structure, the scutes (bony external plates) of the armored Bronze Corydoras Catfish (Corydoras aeneus). Scutes in this model fish species were analyzed via three complementary approaches. First, scutes were documented throughout fish development via high-quality microscope images. These images were subsequently used to inform fabrication of synthetic models to characterize the relationship between scute overlap and overall bending stiffness of scute ...


Evolution Of Gene Regulation In Association With The Origin Of Armor In Stickleback Fishes, Hannah Ghasemi, David Stock Jan 2019

Evolution Of Gene Regulation In Association With The Origin Of Armor In Stickleback Fishes, Hannah Ghasemi, David Stock

Undergraduate Honors Theses

Abstract

Whether the origin of novel structures requires extensive novelty at the genetic level remains an important question in Evolutionary Biology. The bony plates in the dermis (inner layer of the skin) of stickleback fishes (Order Gasterosteiformes) are novel structures that arose as a replacement for scales and whose genetic basis is becoming increasingly well-understood. Previous work has identified an enhancer (a short DNA sequence that regulates the expression of neighboring genes) that is necessary for the expression of the Ectodysplasin (Eda) gene in the bony dermal plates of the Threespine Stickleback (Gasterosteus aculeatus). This gene is necessary for the ...


Genes Regulating Cell Movement During Regeneration In Drosophila Melanogaster Following Radiation Damage, Michelle Ledru Jan 2019

Genes Regulating Cell Movement During Regeneration In Drosophila Melanogaster Following Radiation Damage, Michelle Ledru

Undergraduate Honors Theses

Each year, 1.7 million people are diagnosed with cancer and 610,000 people die from the disease (“Cancer Statistics,” 2018). Ionizing radiation therapy is a commonly used method of treatment for many cancers because it kills cancer cells (Baskar et al., 2012). However, cancer cells that have not been eradicated can proliferate, leading to resistance to treatment (Hanahan & Weinberg, 2011). Drosophila melanogasteris an excellent model organism because they have a short life cycle and share 75% of human disease-causing genes, while the larvae can withstand high amounts of radiation and have regenerative properties. Different genes were investigated to ...