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Articles 1 - 15 of 15

Full-Text Articles in Life Sciences

Socially Regulated Neural Circuits Activation Via Endocannabinoid And Dopaminergic Signaling In Zebrafish, Choongseok Park May 2019

Socially Regulated Neural Circuits Activation Via Endocannabinoid And Dopaminergic Signaling In Zebrafish, Choongseok Park

Biology and Medicine Through Mathematics Conference

No abstract provided.


Bifurcation Analysis Of A Photoreceptor Interaction Model For Retinitis Pigmentosa, Anca R. Radulescu May 2019

Bifurcation Analysis Of A Photoreceptor Interaction Model For Retinitis Pigmentosa, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.


Spiking Activity In Networks Of Neurons Impacted By Axonal Swelling, Brian Frost, Stan Mintchev May 2019

Spiking Activity In Networks Of Neurons Impacted By Axonal Swelling, Brian Frost, Stan Mintchev

Biology and Medicine Through Mathematics Conference

No abstract provided.


A Model Of Online Latent State Learning, Amy Cochran May 2019

A Model Of Online Latent State Learning, Amy Cochran

Biology and Medicine Through Mathematics Conference

No abstract provided.


Predicting Dynamics From Hardwiring In Canonical Low-Dimensional Coupled Networks, Anca R. Radulescu May 2019

Predicting Dynamics From Hardwiring In Canonical Low-Dimensional Coupled Networks, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.


The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin May 2019

The 5-Ht1a-R Knockout Mouse As A Model Of Later Life Anxiety Disorders: Implications For Sex Differences, Tatyana Budylin

All Dissertations, Theses, and Capstone Projects

Anxiety affects nearly twice as many women as it affects men across all cultures and economic groups. Importantly, girls have a higher chance of inheriting anxiety disorders than boys, and many anxiety disorders appear at a very young age. However, little is known about sex differences in brain and behavioral development and how they relate to anxiety in adulthood. Serotonin 1A receptor (5-HT1A-R) mediated signaling has been implicated in depression and anxiety, however most studies that focus on the involvement of the 5-HT1A-R have been conducted in adults. Little is known about how the 5-HT1A ...


Brain Network Structure And Interventions In A Computational Model Of Epilepsy, Joe Emerson Apr 2019

Brain Network Structure And Interventions In A Computational Model Of Epilepsy, Joe Emerson

Student Symposium

Some forms of drug-resistant epilepsy can only be treated via surgical intervention. This form of treatment requires the removal of a part of the brain identified as the seizure source. Current methods for surgical treatment are risky and many times unsuccessful. A deeper understanding of how brain connectivity facilitates seizure propagation is necessary for developing improved surgical techniques. Experimental limitations make certain clinical investigations of epilepsy difficult or impossible, but computational modeling offers a way forward when experimentation in living systems is impractical or unsafe. We used a full-hemisphere computational model for epilepsy to investigate the role of network structure ...


Implicit Versus Explicit Learning Assessments Of Neuroscience Concepts In Undergraduates, Sarah Wonsidler, Noah C. Yeagley Apr 2019

Implicit Versus Explicit Learning Assessments Of Neuroscience Concepts In Undergraduates, Sarah Wonsidler, Noah C. Yeagley

Neuroscience Presentations

No abstract provided.


Sex Differences And Motor Skills In Aging Mice, Anna Beltramini, Terence Bazzett, Molly Brady, Josh Boyer, Ellayna Fredericks, Andrew Guido, Taylor Brophy Apr 2019

Sex Differences And Motor Skills In Aging Mice, Anna Beltramini, Terence Bazzett, Molly Brady, Josh Boyer, Ellayna Fredericks, Andrew Guido, Taylor Brophy

Papers, Posters, and Recordings

With an ever-increasing average human lifespan, a growing area of research is concerned with debilitating neurodegenerative diseases. Parkinson’s and Huntington’s disease (HD) are neurodegenerative disorder in which degradation of cells is observed. Thus, development of useful and sensitive measures of motor coordination in animal models is paramount in advancing basic research.

In this preliminary study, C57/BLJ mice were tested in novel paw reaching chambers used to evaluate fine motor coordination. The same animals were also tested in a grip-strength apparatus, a well-established device designed to measure muscle strength. Measures from both tests will then be correlated to ...


Fostering Stem Interest In Elementary Schools Students Through Neuroscience: A Look At Community Outreach In Geneseo's Rkids After-School Program, Anna Beltramini, Annika Mounts, Jackson Pulizzi, Terence Bazzett, Kate Regner Apr 2019

Fostering Stem Interest In Elementary Schools Students Through Neuroscience: A Look At Community Outreach In Geneseo's Rkids After-School Program, Anna Beltramini, Annika Mounts, Jackson Pulizzi, Terence Bazzett, Kate Regner

Papers, Posters, and Recordings

As a way to encourage community service and application based learning, NEUR 215: Applications in Neuroscience connects students at Geneseo with underserved children in the surrounding community. As in previous semesters, children in 3rd-5th grade who participate in this enrichment program benefit from weekly tutoring sessions, but the goal of this course is to further engage them in interactive learning through neuroscience related activities. Additionally, the experience of being on campus and interacting within a college setting can be used to stimulate a positive association with higher education. Sessions are designed with the intention of creating an enjoyable learning environment ...


Law, Responsibility, And The Brain, Owen D. Jones, Hakwan C. Lau, Dean Mobbs, Christopher D. Frith Apr 2019

Law, Responsibility, And The Brain, Owen D. Jones, Hakwan C. Lau, Dean Mobbs, Christopher D. Frith

Owen Jones

This article addresses new developments in neuroscience, and their implications for law. It explores, for example, the relationships between brain injury and violence, as well as the connections between mental disorders and criminal behaviors. It discusses a variety of issues surrounding brain fingerprinting, the use of brain scans for lie detection, and concerns about free will. It considers the possible uses for, and legal implications of, brain-imaging technology. And it also identifies six essential limits on the use of brain imaging in courtroom procedures.


An Effective Model For Engaging Faculty And Undergraduate Students In Neuroscience Outreach With Middle Schoolers, Peter J. Vollbrecht, Riley S. Frenette, Andrew J. Gall Apr 2019

An Effective Model For Engaging Faculty And Undergraduate Students In Neuroscience Outreach With Middle Schoolers, Peter J. Vollbrecht, Riley S. Frenette, Andrew J. Gall

Faculty Publications

Engaging undergraduate students in science outreach events is critical for improving future communication between scientists and community members. Outreach events are opportunities for faculty and undergraduates to utilize active learning strategies to engage non-scientists in scientific questions and principles. Through careful design of outreach events, undergraduate students can practice science communication skills while reaching populations of the public that remain underserved and underrepresented in scientific fields. Here we describe a classroom outreach event designed to give a broad overview of the field of neuroscience to middle school students of all backgrounds by delivering the content in school, during school hours ...


Childhood And Trauma: The Effects Of Adverse Childhood Experiences On The Brain, Behavior, And Learning In The Elementary School Classroom, Aeryn Aguilar Jan 2019

Childhood And Trauma: The Effects Of Adverse Childhood Experiences On The Brain, Behavior, And Learning In The Elementary School Classroom, Aeryn Aguilar

Theses and projects

A variety of studies have been conducted on how trauma, caused by emotional, physical, or verbal abuse, impact children’s lives. Many of the studies which involved observations and assessments were done with the preexisting knowledge that these children had been through a traumatic experience. Instead of looking at behavior of known cases, this study’s goal is to find out whether or not children’s observable behaviors can predict cases of trauma. For example, is acting out or defiance a key sign of trauma or is it part of the typical development for the elementary school-age group? This thesis ...


A Composite Review Of The Proposed Molecular Mechanisms And Genetic Components Underlying Parkinson’S Disease, Paige Brodrick Jan 2019

A Composite Review Of The Proposed Molecular Mechanisms And Genetic Components Underlying Parkinson’S Disease, Paige Brodrick

Scripps Senior Theses

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the progressive death of dopaminergic neurons present in the substantia nigra. The clinical presentation of PD includes tremors, slowed movement (bradykinesia), muscle and limb rigidity, and difficulty with walking and balancing. While many environmental factors can affect the onset and progression of the disease, genetic mutations have a large influence. Of the identified PD-linked genetic mutations, mutations in the leucine-rich repeat kinase 2 (LRRK2) are one of the most common genetic causes of PD. Located in endosomes, LRRK2 has been shown to play a role in the sorting and ...


The Characterization Of Alzheimer’S Disease And The Development Of Early Detection Paradigms: Insights From Nosology, Biomarkers And Machine Learning, Isabel Milano Jan 2019

The Characterization Of Alzheimer’S Disease And The Development Of Early Detection Paradigms: Insights From Nosology, Biomarkers And Machine Learning, Isabel Milano

CMC Senior Theses

Alzheimer’s Disease (AD) is the only condition in the top ten leading causes of death for which we do not have an effective treatment that prevents, slows, or stops its progression. Our ability to design useful interventions relies on (a) increasing our understanding of the pathological process of AD and (b) improving our ability for its early detection. These goals are impeded by our current reliance on the clinical symptoms of AD for its diagnosis. This characterizations of AD often falsely assumes a unified, underlying AD-specific pathology for similar presentations of dementia that leads to inconsistent diagnoses. It also ...