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Full-Text Articles in Life Sciences

Investigating The Effects Of Cancer Mutations On The Mrn Complex Using Yeast, Caitlin Harris Apr 2019

Investigating The Effects Of Cancer Mutations On The Mrn Complex Using Yeast, Caitlin Harris

Spring Showcase for Research and Creative Inquiry

A screening method using yeast to determine which cancer mutations disrupt the function of Mre11 after exposure to DNA damaging agents.


The Effects Of Releasing Balloons: Soft Plastic Pollution In Our Oceans, Morgan Pearce, Nicole Copenhaver Apr 2019

The Effects Of Releasing Balloons: Soft Plastic Pollution In Our Oceans, Morgan Pearce, Nicole Copenhaver

Spring Showcase for Research and Creative Inquiry

Our art piece is intended to showcase how balloons are killing sea animals, like sea turtles, whale, and birds. We wanted to use re-purposed balloons in our piece to draw our audiences attention with brightly colored balloons and to create an actual sense of balloons. We made the animals out of mud stencils to connect the the natural resource of mud to wildlife.


The Future Of Invasive Species, Taylor Clements, Tiffany Yun, Sam Kane, Aryana Dipippa Apr 2019

The Future Of Invasive Species, Taylor Clements, Tiffany Yun, Sam Kane, Aryana Dipippa

Spring Showcase for Research and Creative Inquiry

End of semester group project on the management of invasive species based on peer-review articles.


The Role Of Capsaicin And [6]-Gingerol In Preventing​ Cancer Through Altering Immunity ​, Emery F. Chittenden, Taylor Clements, Tessa E. Dewalt, Erica L. Harris Apr 2019

The Role Of Capsaicin And [6]-Gingerol In Preventing​ Cancer Through Altering Immunity ​, Emery F. Chittenden, Taylor Clements, Tessa E. Dewalt, Erica L. Harris

Spring Showcase for Research and Creative Inquiry

No abstract provided.


The Role Of Plastic Debris Found In The Loggerhead Sea Turtle's Digestive Tract & How It Effects The Reproduction Survival Rate, Taylor Clements Apr 2019

The Role Of Plastic Debris Found In The Loggerhead Sea Turtle's Digestive Tract & How It Effects The Reproduction Survival Rate, Taylor Clements

Spring Showcase for Research and Creative Inquiry

No abstract provided.


Observing The Cooperation Of Varroa Destructor And Dna Virus Amfv In The Onset Of Colony Collapse Disorder In Emerging Apis Mellifera, Rex Liggon Apr 2019

Observing The Cooperation Of Varroa Destructor And Dna Virus Amfv In The Onset Of Colony Collapse Disorder In Emerging Apis Mellifera, Rex Liggon

Spring Showcase for Research and Creative Inquiry

The honey bee population is declining from the onset of a disorder known as Colony Collapse Disorder (CCD) which has been associated with climate change, increase use of insecticides, and parasite/viral communication. Much focus has been directed towards the communication between RNA viruses with the honey bee parasite Varroa destructor and their relationship to haemolymph levels in emerging worker bees, but their association with DNA viruses has been neglected. The study proposed is to closely observe whether parasite burden in combination with reduced haemolymph levels could increase viral replication of DNA virus AmFV in emerging honey worker bees. Since ...


Restoring The Population Of Keystone Species In The Chesapeake Bay: How The Preservation Of Submerged Aquatic Vegetation Can Improve The Blue Crab Population, Christina Bell Apr 2019

Restoring The Population Of Keystone Species In The Chesapeake Bay: How The Preservation Of Submerged Aquatic Vegetation Can Improve The Blue Crab Population, Christina Bell

Spring Showcase for Research and Creative Inquiry

A research proposal poster that describes the possible relationship between juvenile Blue Crab survival and submerged aquatic vegetation density.


Better Gene, Better Beer, Caitlin Harris, Marcia Lanasa, Jess Cagnina Apr 2019

Better Gene, Better Beer, Caitlin Harris, Marcia Lanasa, Jess Cagnina

Spring Showcase for Research and Creative Inquiry

Investigating the flocculation gene, Flo11, in different brewing yeast strains to determine variations that could be contributing to the different levels of flocculation in beer.


Long-Term Aerobic Exercise Can Enhance Cognition And Delya The Onset Of Alzheimer's Disease, Juliana Gordon Apr 2019

Long-Term Aerobic Exercise Can Enhance Cognition And Delya The Onset Of Alzheimer's Disease, Juliana Gordon

Spring Showcase for Research and Creative Inquiry

Aerobic exercise programs have been shown to enhance cognition, functional ability, and may be a great, cost efficient therapeutic strategy for patients suffering from Alzheimer’s disease. Can a long-term (15-year long) aerobic exercise program be used as a preventative therapeutic strategy to delay or prevent the onset of Alzheimer’s disease? Some potential outcomes of this study could be that long-term aerobic exercise effectively delays the onset of Alzheimer’s disease in individuals at high risk for developing Alzheimer’s disease and that long-term aerobic exercise will enhance cognition, functional ability, and decrease losses in hippocampal volume that occur ...


The Comparative Role Of Tail Feathers In American Goldfinches (Spinus Tristis), Colin Dominick Apr 2019

The Comparative Role Of Tail Feathers In American Goldfinches (Spinus Tristis), Colin Dominick

Spring Showcase for Research and Creative Inquiry

Investigating the aerodynamic effects of the tail in solo vs. interactive flight comparatively.


The Connection Between Emotional Stress And Developing Graves' Disease, Andrea Leigh Soles Apr 2019

The Connection Between Emotional Stress And Developing Graves' Disease, Andrea Leigh Soles

Spring Showcase for Research and Creative Inquiry

Graves’ disease is an autoimmune disease where the body’s immune system attacks the thyroid and causes the overproduction of thyroid hormone. It also causes hyperthyroidism where the thyroid is essentially in hyperdrive. This study aimed to identify the effects of long-term emotional stress on the development of Graves’ disease. More specifically, it looked to see if this type of stress triggered the overabundance of thyroid-stimulating immunoglobulins (TSIs), the antibodies that attack the thyroid, causing growth and the production of too much thyroid hormone. The expected outcome is that that the participants that have not been officially diagnosed with the ...


Von Willebrand Disease: The Viability Of A Technology-Based Diagnostic Modality, Theodore Gutches Apr 2019

Von Willebrand Disease: The Viability Of A Technology-Based Diagnostic Modality, Theodore Gutches

Spring Showcase for Research and Creative Inquiry

Von Willebrand disease (VWD) is an autosomal inherited bleeding disorder in which a person is deficient, qualitatively and/or quantitatively, in an essential enzyme for the coagulation pathway, von Willebrand factor (VWF). Like many coagulation disorders, the disease is commonly classified into three subtypes that include varying degrees of severity. More specifically, type 1 is classified as a partial quantitative deficiency in the VWF, type 2 as a qualitative deficiency, and type 3 as a total deficiency. As to be expected, the importance of proper diagnosis and treatment of VWD in a clinical setting, either for surgical precautions or general ...


The Role Of Genetics With Alcoholism And Its Effects On Genes Aldh2, Adh1b By Causing Mutations In The Genome, Erica L. Harris Apr 2019

The Role Of Genetics With Alcoholism And Its Effects On Genes Aldh2, Adh1b By Causing Mutations In The Genome, Erica L. Harris

Spring Showcase for Research and Creative Inquiry

Alcohol use disorder, an illness described by harmful drinking patterns leading to negative ramifications both emotional and physical, has become more predominantly associated with genetics rather than behavioral. There are many factors that play into alcoholism, some being environmental, heritability, and now genetics related. There are two genes believed to be related to alcoholism, ADH1B and ALDH2. Alcoholism can lead to cirrhosis of the liver, cancer and necrosis. In efforts to understanding the role of genetics and alcoholism, a genome mapping evaluation would allow for researchers to understand the effect of alcoholism and the role of genes ALDH2 and ADH1B ...


Methyl And Butyl-Parabens Initiate Myeloid Derived Suppressor Cell (Mdsc) Activity, Amanda Moses, Sandra Ghali, Tiffany Yun, Juwairyah Gunter Apr 2019

Methyl And Butyl-Parabens Initiate Myeloid Derived Suppressor Cell (Mdsc) Activity, Amanda Moses, Sandra Ghali, Tiffany Yun, Juwairyah Gunter

Spring Showcase for Research and Creative Inquiry

Examined if methyl and butyl parabens would mimic estrogen within the body and lead to an increase in MDSC activity


Proposal For Curing Multiple Sclerosis By Genetically Engineering Obligodendrocytes, Amanda Moses Apr 2019

Proposal For Curing Multiple Sclerosis By Genetically Engineering Obligodendrocytes, Amanda Moses

Spring Showcase for Research and Creative Inquiry

A novel proposal to find a cure for multiple sclerosis by genetically engineering neural stem cells with chemotherapy and the three key myelin producing genes to help promote remyelination on the myelin sheath, thereby removing lesions and symptoms of the disease.


Successfulness Of Live Capture Eradication Efforts Of The Golden Eagle On The Channel, Rana Haboush Apr 2019

Successfulness Of Live Capture Eradication Efforts Of The Golden Eagle On The Channel, Rana Haboush

Spring Showcase for Research and Creative Inquiry

Study the eradication efforts of the Golden Eagle on the Channel Island Fox, and determine the successfulness of the eradication efforts implemented.


Postural Orthostatic Tachycardia Syndrome In Relation To Anxiety And Cognitive Impairments, Lyndi Earnshaw Apr 2019

Postural Orthostatic Tachycardia Syndrome In Relation To Anxiety And Cognitive Impairments, Lyndi Earnshaw

Spring Showcase for Research and Creative Inquiry

Postural Orthostatic Tachycardia Syndrome (POTS) is a heterogeneous syndrome that is a form of orthostatic intolerance. When a patient with POTS stands their heart rate rapidly increases. Other symptoms that are caused by POTS are: lightheadedness, dizziness, chest pain, fatigue, heart palpitations, and rapid heart rate. There has been limited research on this syndrome, but there has been some evidence indicating that anxiety can be increased in patients, as well as cognitive impairments such as lower IQ and slower response time as well. Different cognitive tests will be conducted as well as anxiety testing through State-Trait Anxiety Inventory (STAI), on ...


The Effect Of Ethyl And Butyl Parabens To Mimic Estrogen To Alter Differentiation Of Myeloid Derived Suppressor Cells, Lyndi Earnshaw, Jessica Savas, Caitlin Harris, Rayven Brown, Annie Choi Apr 2019

The Effect Of Ethyl And Butyl Parabens To Mimic Estrogen To Alter Differentiation Of Myeloid Derived Suppressor Cells, Lyndi Earnshaw, Jessica Savas, Caitlin Harris, Rayven Brown, Annie Choi

Spring Showcase for Research and Creative Inquiry

Estrogens have been proven to increase estrogenic activity seen in some cancers. Our research aims to elucidate the effects of xenoestrogens, specifically parabens, on the same oncogenic mechanisms. To compare the effects of ethyl and butyl parabens to natural estrogen, T cell activation and proliferation was measured after exposure to each compound. Understanding the potential effects of parabens as estrogen agonists would allow for safer regulations for use in common food and health products


Double Gene Knockout Of Pdx-1 And Hnf1Β Leads To Possible Novel Gene Therapy For Type 1 Diabetes, Kathryn Kosiorek Apr 2019

Double Gene Knockout Of Pdx-1 And Hnf1Β Leads To Possible Novel Gene Therapy For Type 1 Diabetes, Kathryn Kosiorek

Spring Showcase for Research and Creative Inquiry

Diabetes Mellitus is a disease characterized by uncontrolled and elevated blood glucose which is the effect of inadequate levels of plasma insulin. Type I diabetes (T1D) ultimately stems from the autoimmune destruction of beta cells because of defects in the PDX-1 and possibly HNF1B. If both of these genes knocked out together increase the detriment effect of T1D, then a gene therapy can be created using the AAV vectors that not only targets one gene but both at the same time, increasing the strength of the gene therapy and the quality of life for the T1D patient.


Modifying The Effects Of Aβ40 And Aβ42 Proteins In Patients With Alzheimer's Disease, Angelica Romero Apr 2019

Modifying The Effects Of Aβ40 And Aβ42 Proteins In Patients With Alzheimer's Disease, Angelica Romero

Spring Showcase for Research and Creative Inquiry

My project looks over the effects of two proteins that induce memory loss in the brain for patients with Alzheimer's Disease. My proposal is to modify these proteins in order to create a type of therapy for people diagnosed with this insufferable disease.


Enhancement Of Macrophage Response O N. Gonorrhea Infection, Sandra Ghali Apr 2019

Enhancement Of Macrophage Response O N. Gonorrhea Infection, Sandra Ghali

Spring Showcase for Research and Creative Inquiry

My project focuses on enhancing the natural immune response to gonorrhea infection via the engineering of bispecific lectins that attach gonorrhea to the immune cells and induces phagocytosis.


The Role Of Genome Mapping In Diagnosing Bipolar Disorder, Emery F. Chittenden Apr 2019

The Role Of Genome Mapping In Diagnosing Bipolar Disorder, Emery F. Chittenden

Spring Showcase for Research and Creative Inquiry

Genome mappings as a mechanism for diagnosis in bipolar disorder.


Investigating The Effects Of Cancer Mutations On The Activity Of P300, Meghan Hall Apr 2019

Investigating The Effects Of Cancer Mutations On The Activity Of P300, Meghan Hall

Spring Showcase for Research and Creative Inquiry

Investigating the effects of cancer mutations on the activity of p300


Thermal Safety Of Childrens Outdoor Play Equipment, Adam Gyori Apr 2019

Thermal Safety Of Childrens Outdoor Play Equipment, Adam Gyori

Spring Showcase for Research and Creative Inquiry

A literature review looking into the newer field of research in the thermal regulation of children’s outdoor play equipment and its effects it may be causing to the health of children.


Punicic Acid As A Possible Supplemental Treatment For Adolescent Type I Diabetes, Murriel Grimes Apr 2019

Punicic Acid As A Possible Supplemental Treatment For Adolescent Type I Diabetes, Murriel Grimes

Spring Showcase for Research and Creative Inquiry

Investigating the potential for punicic acid to be combined with insulin to treat type I diabetes.


The Effects Of Pramipexole And Carbidopa-Levodopa On Blocking Abnormal Activity In Gene Lrrk2 Which Causes Loss Of Dopaminergic Neurons In Parkinsons, Tiffany Yun Apr 2019

The Effects Of Pramipexole And Carbidopa-Levodopa On Blocking Abnormal Activity In Gene Lrrk2 Which Causes Loss Of Dopaminergic Neurons In Parkinsons, Tiffany Yun

Spring Showcase for Research and Creative Inquiry

Parkinsons is a neurodegenerative disorder that causes damage to dopaminergic neurons in the brain that are essential for controlling movement. There is no cure for this disease but scientists have found sources of treatments that help control the symptoms like using dopamine agonists which mimic dopamine effects and Carbidopa-levodopa which is converted into dopamine. This study aims to identify the different effects of using Pramipexole and Carbidopa-levodopa on blocking the activity of the mutated gene LRRK2 which is known to result in the loss of dopaminergic neurons in Parkinson. This study could have three potential conclusions where there is a ...


Ccl21 Protein Leads To Advancements In Understanding Lung Transplant Rejection, Cecilie Elliott Apr 2019

Ccl21 Protein Leads To Advancements In Understanding Lung Transplant Rejection, Cecilie Elliott

Spring Showcase for Research and Creative Inquiry

: The hypothesis of this experiment is that with an increase of the chemokine CCL21, those who have had a lung transplant will have an increase in the overall survival rate. This process would occur by increasing the immune response to recognize a new organ as “normal” instead of foreign and dangerous. The specific aim of this study targets to reduce the rejection in post lung transplant subjects by increasing the amount of CCL21 by injecting the DC/CCL21 vaccination to express T and B cells more efficiently. Mice would be injected with an IPF (Idiopathic Pulmonary Fibrosis) cell line to ...


Ability Of Flavonoids To Mimic The Estrogen Receptor To Drive Myeloid Derived Suppressor Cell Differentiation, Megan Bland, Cecilie Elliott, Kathryn Kosiorek Apr 2019

Ability Of Flavonoids To Mimic The Estrogen Receptor To Drive Myeloid Derived Suppressor Cell Differentiation, Megan Bland, Cecilie Elliott, Kathryn Kosiorek

Spring Showcase for Research and Creative Inquiry

Flavonoids are natural compounds found in dietary elements such as soy, grains, and vegetables that have the potential to bind to the estrogen receptor. Activation of the estrogen receptor drives myeloid derived suppressor cell (MDSC) accumulation, cells that increase during cancer, inflammation, and infection. In this study, we are investigating specific flavonoids, such as epigallocatechin-3-gallate (EGCG), kaempferol, naringenin, daidzein, and genistein, for their ability to mimic estrogen. After examination, we expect that MDSC differentiation will decrease upon treatment of the chosen flavonoids, leading to reduced carcinogenic effects.


It's High Time, Rana Haboush, Taylor Mattison, Angelica Romero Apr 2019

It's High Time, Rana Haboush, Taylor Mattison, Angelica Romero

Spring Showcase for Research and Creative Inquiry

Our Specific Aim is to discuss the major impacts of sea level rise. We display how art can be used to spread awareness by creating before and after posters of a well-known monument effected by sea-level rise.


The Use Hela Derived Telomerase On Nk Cells In The Treatment Of Ovarian Cancer, Juwairyah Gunter Apr 2019

The Use Hela Derived Telomerase On Nk Cells In The Treatment Of Ovarian Cancer, Juwairyah Gunter

Spring Showcase for Research and Creative Inquiry

A research proposal for a novel immunotherapy for treating ovarian cancer.