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Full-Text Articles in Life Sciences

Pancreas Of Coxsackievirus-Infected Dams And Their Challenged Pups: A Complex Issue, Sona Sarmirova, Maria Borsanyiova, Brigita Benkoova, Michaela Pospisilova, Rajkumar Rajasekaran, Katarina Berakova, Pavol Gomolcak, Jay Reddy, Shubhada Bopegamage Jan 2019

Pancreas Of Coxsackievirus-Infected Dams And Their Challenged Pups: A Complex Issue, Sona Sarmirova, Maria Borsanyiova, Brigita Benkoova, Michaela Pospisilova, Rajkumar Rajasekaran, Katarina Berakova, Pavol Gomolcak, Jay Reddy, Shubhada Bopegamage

Papers in Veterinary and Biomedical Science

Enteroviral infections are frequent, often asymptomatic in humans and during gravidity. The present study is an extension of our previous investigations where we had shown pancreatitis in challenged pups of CVB4-E2-infected dams. Present investigation describes the effect of gestational infection with this virus on the pancreas of both dams and their challenged pups. Gravid CD1 outbred mice were orally infected with CVB4-E2 virus at different gestation times. Pups were challenged orally with the same virus after 25 days of birth. Organs were collected at selected intervals postinfection (p.i.), and replicating virus and viral-RNA copies were analyzed. Additional readouts included ...


A Potential New Tool For The Toolbox: Assessing Gene Drives For Eradicating Invasive Rodent Populations, K. J. Campbell, J.R. Saah, P.R. Brown, J. Godwin, G.R. Howald, A. Piaggio, P. Thomas, D.M. Tompkins, D. Threadgill, J. Delborne, D.M. Kanavy, T. Kuiken, H. Packard, M. Serr, A. Shiels Jan 2019

A Potential New Tool For The Toolbox: Assessing Gene Drives For Eradicating Invasive Rodent Populations, K. J. Campbell, J.R. Saah, P.R. Brown, J. Godwin, G.R. Howald, A. Piaggio, P. Thomas, D.M. Tompkins, D. Threadgill, J. Delborne, D.M. Kanavy, T. Kuiken, H. Packard, M. Serr, A. Shiels

USDA National Wildlife Research Center - Staff Publications

Invasive rodents have significant negative impacts on island biodiversity. All but the smallest of rodent eradications currently rely on island-wide rodenticide applications. Although significant advances have been made in mitigating unintended impacts, rodent eradication on inhabited islands remains extremely challenging. Current tools restrict eradication eff orts to fewer than 15% of islands with critically endangered or endangered species threatened by invasive rodents. The Genetic Biocontrol of Invasive Rodents partnership is an interdisciplinary collaboration to develop and evaluate gene drive technology for eradicating invasive rodent populations on islands. Technological approaches currently being investigated include the production of multiple strains of Mus ...