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Open Access. Powered by Scholars. Published by Universities.®

2019

University of Massachusetts Medical School

T cells

Immunology of Infectious Disease

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Full-Text Articles in Life Sciences

Memory Cd4 T Cell-Derived Il-2 Synergizes With Viral Infection To Exacerbate Lung Inflammation, K. Kai Mckinstry, Fahmida Alam, Valeria Flores-Malavet, Mate Z. Nagy, Stewart Sell, Andrea M. Cooper, Susan L. Swain, Tara M. Strutt Aug 2019

Memory Cd4 T Cell-Derived Il-2 Synergizes With Viral Infection To Exacerbate Lung Inflammation, K. Kai Mckinstry, Fahmida Alam, Valeria Flores-Malavet, Mate Z. Nagy, Stewart Sell, Andrea M. Cooper, Susan L. Swain, Tara M. Strutt

Open Access Articles

Defining the most penetrating correlates of protective memory T cells is key for designing improved vaccines and T cell therapies. Here, we evaluate how interleukin (IL-2) production by memory CD4 T cells, a widely held indicator of their protective potential, impacts immune responses against murine influenza A virus (IAV). Unexpectedly, we show that IL-2-deficient memory CD4 T cells are more effective on a per cell basis at combating IAV than wild-type memory cells that produce IL-2. Improved outcomes orchestrated by IL-2-deficient cells include reduced weight loss and improved respiratory function that correlate with reduced levels of a broad array of ...