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Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

2019

The University of Maine

CpsA

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Determining Key Residues Of The Lyt-R Domain In The Streptococcal Cpsa Protein, Mohammad Hashmi Apr 2019

Determining Key Residues Of The Lyt-R Domain In The Streptococcal Cpsa Protein, Mohammad Hashmi

Honors College

Streptococcus agalactiae or Group B Streptococcus (GBS), is a Gram-positive commensal bacterium that is harmless in healthy adults, yet causes systemic diseases in neonates, the elderly, and immunocompromised individuals. Neonates are at risk of GBS infection in utero or during delivery due to the colonization of the organism in the vaginal canal of between 15-30% of adult females. GBS can cause severe neonatal sepsis and meningitis, as well as chorioamnionitis, which can cause premature birth and stillbirth. GBS infection is greatly facilitated by the presence of a bacterial capsule; a protective, polysaccharide matrix surrounding the cell that plays a key ...


Construction Of A Cpsa Double Mutant To Determine The Function Of The Lyt-R Domain, Klarissa Klier Apr 2019

Construction Of A Cpsa Double Mutant To Determine The Function Of The Lyt-R Domain, Klarissa Klier

Honors College

Streptococcus agalactiae, otherwise known as Group B Streptococcus (GBS), is a zoonotic, Gram-positive, commensal and invasive bacteria which is the leading cause of neonatal bacterial infections. These bacterial infections include sepsis, meningitis, pneumonia, and bacteremia. In neonates, GBS is most commonly transferred to the child in utero or during birth when the child aspirates amniotic or vaginal fluids. GBS can also infect the child through the bloodstream while in utero, causing premature births or still births. Children who survive the initial infection develop severe morbidities which include mental retardation, cerebral palsy, and seizures. GBS can also affect immunocompromised adults, leading ...