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Full-Text Articles in Life Sciences

Determining Key Residues Of The Lyt-R Domain In The Streptococcal Cpsa Protein, Mohammad Hashmi Apr 2019

Determining Key Residues Of The Lyt-R Domain In The Streptococcal Cpsa Protein, Mohammad Hashmi

Honors College

Streptococcus agalactiae or Group B Streptococcus (GBS), is a Gram-positive commensal bacterium that is harmless in healthy adults, yet causes systemic diseases in neonates, the elderly, and immunocompromised individuals. Neonates are at risk of GBS infection in utero or during delivery due to the colonization of the organism in the vaginal canal of between 15-30% of adult females. GBS can cause severe neonatal sepsis and meningitis, as well as chorioamnionitis, which can cause premature birth and stillbirth. GBS infection is greatly facilitated by the presence of a bacterial capsule; a protective, polysaccharide matrix surrounding the cell that plays a key ...


Determining The Key Residues For Capsule Production In The Gbs Cpsa Protein, Anna Struba Apr 2019

Determining The Key Residues For Capsule Production In The Gbs Cpsa Protein, Anna Struba

Honors College

Streptococcus agalactiae (GBS) is a common bacterium found commensally in the vaginal mucosa of healthy adults. GBS also causes severe infection in neonates, often leading to meningitis, which can cause lifelong health consequences including impaired hearing and seizures. Infection of newborns mainly arises from a colonized mother, either before birth through ascending infection or during labor. Ascending infection, where the bacteria travel to the fetus from the vaginal mucosa, is especially concerning as it can lead to loss of pregnancy or premature birth. The most common method of neonatal GBS disease prevention is antibiotic prophylaxis during delivery, though this method ...