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Open Access. Powered by Scholars. Published by Universities.®

2019

The University of Maine

Agalactiae

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Determining Key Residues Of The Lyt-R Domain In The Streptococcal Cpsa Protein, Mohammad Hashmi Apr 2019

Determining Key Residues Of The Lyt-R Domain In The Streptococcal Cpsa Protein, Mohammad Hashmi

Honors College

Streptococcus agalactiae or Group B Streptococcus (GBS), is a Gram-positive commensal bacterium that is harmless in healthy adults, yet causes systemic diseases in neonates, the elderly, and immunocompromised individuals. Neonates are at risk of GBS infection in utero or during delivery due to the colonization of the organism in the vaginal canal of between 15-30% of adult females. GBS can cause severe neonatal sepsis and meningitis, as well as chorioamnionitis, which can cause premature birth and stillbirth. GBS infection is greatly facilitated by the presence of a bacterial capsule; a protective, polysaccharide matrix surrounding the cell that plays a key ...